TY - JOUR
T1 - No evidence for structural brain changes in young adolescents at ultra high risk for psychosis
AU - Ziermans, Tim B.
AU - Durston, Sarah
AU - Sprong, Mirjam
AU - Nederveen, Hilde
AU - van Haren, Neeltje E.M.
AU - Schnack, Hugo G.
AU - Lahuis, Bertine E.
AU - Schothorst, Patricia F.
AU - van Engeland, Herman
PY - 2009/7
Y1 - 2009/7
N2 - Objective: The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). Methods: Structural MRI data from young UHR subjects (n = 54) and typically developing, matched controls (n = 54) were acquired with a 1.5 Tesla scanner and compared. Results: None of the measures differed between UHR subjects and controls. Conclusions: Our results do not support the presence of gross neuroanatomical changes in young UHR subjects. This suggests that early changes are too subtle to detect with conventional imaging techniques. Therefore, changes observed in older cohorts may only onset later developmentally or occur secondary to prodromal symptoms.
AB - Objective: The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). Methods: Structural MRI data from young UHR subjects (n = 54) and typically developing, matched controls (n = 54) were acquired with a 1.5 Tesla scanner and compared. Results: None of the measures differed between UHR subjects and controls. Conclusions: Our results do not support the presence of gross neuroanatomical changes in young UHR subjects. This suggests that early changes are too subtle to detect with conventional imaging techniques. Therefore, changes observed in older cohorts may only onset later developmentally or occur secondary to prodromal symptoms.
UR - http://www.scopus.com/inward/record.url?scp=67349189494&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2009.04.013
DO - 10.1016/j.schres.2009.04.013
M3 - Article
C2 - 19419840
AN - SCOPUS:67349189494
SN - 0920-9964
VL - 112
SP - 1
EP - 6
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -