No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis

Rob Verdijk; Werner Ouwendijk; Robert Kuijpers; Georges Verjans

doi:10.1093/infdis/jiaa566

No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis

Rob Verdijk, Werner Ouwendijk, Robert Kuijpers, Georges Verjans

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

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Abstract

Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	The Journal of infectious diseases
Volume	223
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiaa566
Publication status	Published - 1 Jan 2021

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© 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America.

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title = "No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis",

abstract = "Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.",

author = "Rob Verdijk and Werner Ouwendijk and Robert Kuijpers and Georges Verjans",

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No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis. / Verdijk, Rob ; Ouwendijk, Werner ; Kuijpers, Robert et al.
In: The Journal of infectious diseases, Vol. 223, No. 1, 01.01.2021, p. 109-112.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis

AU - Verdijk, Rob

AU - Ouwendijk, Werner

AU - Kuijpers, Robert

AU - Verjans, Georges

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

AB - Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

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DO - 10.1093/infdis/jiaa566

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SN - 0022-1899

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JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 1

ER -

No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis

Abstract

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