No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

SA Ivanova; Asmar Al Hadithy; N Brazovskaya; A Semke; B Wilffert; O Fedorenko; JRBJ Brouwers; AJM Loonen

doi:10.1002/hup.2226

No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

SA Ivanova, Asmar Al Hadithy, N Brazovskaya, A Semke, B Wilffert, O Fedorenko, JRBJ Brouwers, AJM Loonen

Pharmacy

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright (c) 2012 John Wiley & Sons, Ltd.

Original language	Undefined/Unknown
Pages (from-to)	334-337
Number of pages	4
Journal	Human Psychopharmacology-Clinical and Experimental
Volume	27
Issue number	3
DOIs	https://doi.org/10.1002/hup.2226
Publication status	Published - 2012

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EMC OR-01-34-01

Access to Document

10.1002/hup.2226

http://hdl.handle.net/1765/61118

Cite this

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title = "No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia",

abstract = "Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright (c) 2012 John Wiley & Sons, Ltd.",

author = "SA Ivanova and {Al Hadithy}, Asmar and N Brazovskaya and A Semke and B Wilffert and O Fedorenko and JRBJ Brouwers and AJM Loonen",

year = "2012",

doi = "10.1002/hup.2226",

language = "Undefined/Unknown",

volume = "27",

pages = "334--337",

journal = "Human Psychopharmacology-Clinical and Experimental",

issn = "0885-6222",

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TY - JOUR

T1 - No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

AU - Ivanova, SA

AU - Al Hadithy, Asmar

AU - Brazovskaya, N

AU - Semke, A

AU - Wilffert, B

AU - Fedorenko, O

AU - Brouwers, JRBJ

AU - Loonen, AJM

PY - 2012

Y1 - 2012

N2 - Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright (c) 2012 John Wiley & Sons, Ltd.

AB - Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright (c) 2012 John Wiley & Sons, Ltd.

U2 - 10.1002/hup.2226

DO - 10.1002/hup.2226

M3 - Article

SN - 0885-6222

VL - 27

SP - 334

EP - 337

JO - Human Psychopharmacology-Clinical and Experimental

JF - Human Psychopharmacology-Clinical and Experimental

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