Non-AIDS Events in Individuals With Spontaneous Control of HIV-1: A Systematic Review

Albert L. Groenendijk, Wilhelm A.J.W. Vos, Jéssica C. Dos Santos, Casper Rokx, Andre J.A.M. van der Ven, Annelies Verbon

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)

Abstract

BACKGROUND: Despite antiretroviral therapy (ART), people living with HIV (PLHIV) are at increased risk for non-AIDS-defining events (nADEs), including cardiovascular events, non-AIDS malignances, hepatic disease, and bacterial pneumonia. SETTING: This systematic review seeks to answer the question: are PLHIV who spontaneously control HIV-1 subject to an increased risk of various nADEs relative to noncontrolling PLHIV on ART and people without HIV? METHODS: Databases were searched on June 9, 2021 with a search syntax focused on the elements "HIV," "spontaneous control," and "clinical outcomes": Embase.com (includes Embase and Medline), Medline Ovid (includes PubMed), Cochrane library, Web of Science, and Google Scholar. Included were studies reporting non-AIDS events in spontaneous controllers. Excluded were case reports, conference papers, editorials, and reviews. RESULTS: Of 1134 identified records, 34 were assessed for full-text and 12 studies were included in the qualitative synthesis: 5 cohorts, 2 cross-sectional prevalence studies, 4 cross-sectional imaging studies, and one case series. Four of 5 cohort studies showed that spontaneous controllers have a similar risk to develop nADEs compared with PLHIV on suppressive ART, specifically cardiovascular events, non-AIDS malignancies, hepatic disease, and bacterial pneumonia. Cross-sectional imaging studies showed a higher presence of subclinical cardiovascular disease in spontaneous controllers, than in people without HIV. CONCLUSION: Individuals with spontaneous control of HIV-1 do not seem to be at a greater risk to develop different nADEs compared with PLHIV on suppressive ART. More data are needed, because the present conclusions are based on a limited number of studies that show large heterogeneity among them.

Original languageEnglish
Pages (from-to)242-250
Number of pages9
JournalJournal of acquired immune deficiency syndromes (1999)
Volume91
Issue number3
DOIs
Publication statusPublished - 1 Nov 2022

Bibliographical note

Funding Information:
A.G., W.A.J.V., J.d.S., C.R., A.J.M.d.V., A.V. are members of the 2000HIV consortium subsidized by ViiV Healthcare. C.R. has received research grants from Gilead, ViiV, Janssen, ZonMW, AIDSfonds, and Health-Holland. C.R. is part of the advisory board for Gilead and ViiV. The remaining authors have no conflicts of interest to disclose.

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.

Fingerprint

Dive into the research topics of 'Non-AIDS Events in Individuals With Spontaneous Control of HIV-1: A Systematic Review'. Together they form a unique fingerprint.

Cite this