Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy

Arjen Amelink; OP Kaspers; Dick Sterenborg; JE van der Wal; JLN Roodenburg; MJH Witjes

doi:10.1016/j.oraloncology.2006.12.011

Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy

Arjen Amelink, OP Kaspers, Dick Sterenborg, JE van der Wal, JLN Roodenburg, MJH Witjes

Radiotherapy

Research output: Contribution to journal › Article › Academic › peer-review

96 Citations (Scopus)

Abstract

Differential path-length spectroscopy (DPS) was used to non-invasively determine the superficial optical properties of oral mucosa in vivo. DPS yields information on physiological parameters such as the mucosal. blood content, the microvascular blood oxygenation and the average micro-vessel diameter as well as on morphological parameters such as the scattering slope and scattering amplitude. DPS measurements were made on normal and cancerous oral mucosa using a novel fiber-optic probe, and were correlated to the histological outcome of punch biopsies taken from the same location. Our data shows that the mucosa of oral squamous cell carcinoma is characterised by a significant decrease in microvascular oxygenation and increase in mucosal. blood content compared to normal oral mucosa as well as a significant decrease in scattering amplitude and increase in scattering slope. (c) 2007 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	65-71
Number of pages	7
Journal	Oral Oncology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.oraloncology.2006.12.011
Publication status	Published - 2008

Research programs

EMC MM-03-32-09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.oraloncology.2006.12.011

http://hdl.handle.net/1765/30266

Cite this

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title = "Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy",

abstract = "Differential path-length spectroscopy (DPS) was used to non-invasively determine the superficial optical properties of oral mucosa in vivo. DPS yields information on physiological parameters such as the mucosal. blood content, the microvascular blood oxygenation and the average micro-vessel diameter as well as on morphological parameters such as the scattering slope and scattering amplitude. DPS measurements were made on normal and cancerous oral mucosa using a novel fiber-optic probe, and were correlated to the histological outcome of punch biopsies taken from the same location. Our data shows that the mucosa of oral squamous cell carcinoma is characterised by a significant decrease in microvascular oxygenation and increase in mucosal. blood content compared to normal oral mucosa as well as a significant decrease in scattering amplitude and increase in scattering slope. (c) 2007 Elsevier Ltd. All rights reserved.",

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T1 - Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy

AU - Amelink, Arjen

AU - Kaspers, OP

AU - Sterenborg, Dick

AU - van der Wal, JE

AU - Roodenburg, JLN

AU - Witjes, MJH

PY - 2008

Y1 - 2008

N2 - Differential path-length spectroscopy (DPS) was used to non-invasively determine the superficial optical properties of oral mucosa in vivo. DPS yields information on physiological parameters such as the mucosal. blood content, the microvascular blood oxygenation and the average micro-vessel diameter as well as on morphological parameters such as the scattering slope and scattering amplitude. DPS measurements were made on normal and cancerous oral mucosa using a novel fiber-optic probe, and were correlated to the histological outcome of punch biopsies taken from the same location. Our data shows that the mucosa of oral squamous cell carcinoma is characterised by a significant decrease in microvascular oxygenation and increase in mucosal. blood content compared to normal oral mucosa as well as a significant decrease in scattering amplitude and increase in scattering slope. (c) 2007 Elsevier Ltd. All rights reserved.

AB - Differential path-length spectroscopy (DPS) was used to non-invasively determine the superficial optical properties of oral mucosa in vivo. DPS yields information on physiological parameters such as the mucosal. blood content, the microvascular blood oxygenation and the average micro-vessel diameter as well as on morphological parameters such as the scattering slope and scattering amplitude. DPS measurements were made on normal and cancerous oral mucosa using a novel fiber-optic probe, and were correlated to the histological outcome of punch biopsies taken from the same location. Our data shows that the mucosa of oral squamous cell carcinoma is characterised by a significant decrease in microvascular oxygenation and increase in mucosal. blood content compared to normal oral mucosa as well as a significant decrease in scattering amplitude and increase in scattering slope. (c) 2007 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.oraloncology.2006.12.011

M3 - Article

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SN - 1368-8375

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SP - 65

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JO - Oral Oncology

JF - Oral Oncology

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