Nonhomologous End-Joining

Dik van Gent; Hanna Ijspeert; Mirjam van der Burg

doi:10.1007/978-4-431-55873-6_13

Nonhomologous End-Joining

Dik van Gent
, Hanna Ijspeert
, Mirjam van der Burg

Research output: Chapter/Conference proceeding › Chapter › Academic

1 Citation (Scopus)

Abstract

Repair of DNA double-strand breaks (DSBs) is indispensable for life. Therefore, most living organisms have at least two pathways to repair these breaks: homologous recombination (HR) and nonhomologous end-joining (NHEJ). HR is the main repair mode for replication-associated DSBs, while NHEJ deals with most other breaks, especially during the G0/G1 phase of the cell cycle. Characterization of the core NHEJ machinery over the past 20 years has been accompanied by elucidation of the genetic basis of several types of severe combined immunodeficiency (SCID) and a better understanding of the mechanisms regulating the choice between HR and NHEJ. In this chapter, we will therefore discuss the NHEJ mechanism along with considerations on DSB repair pathway choice and associated disease phenotypes.

Original language	English
Title of host publication	DNA Replication, Recombination, and Repair
Subtitle of host publication	Molecular Mechanisms and Pathology
Place of Publication	Japan
Publisher	Springer Japan
Pages	341-362
Number of pages	22
ISBN (Electronic)	9784431558736
ISBN (Print)	9784431558712
DOIs	https://doi.org/10.1007/978-4-431-55873-6_13
Publication status	Published - 2016

Bibliographical note

Publisher Copyright: © Springer Japan 2016.

Research programs

EMC MGC-01-12-03
EMC MM-02-72-01

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10.1007/978-4-431-55873-6_13

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T1 - Nonhomologous End-Joining

AU - van Gent, Dik

AU - Ijspeert, Hanna

AU - van der Burg, Mirjam

PY - 2016

Y1 - 2016

N2 - Repair of DNA double-strand breaks (DSBs) is indispensable for life. Therefore, most living organisms have at least two pathways to repair these breaks: homologous recombination (HR) and nonhomologous end-joining (NHEJ). HR is the main repair mode for replication-associated DSBs, while NHEJ deals with most other breaks, especially during the G0/G1 phase of the cell cycle. Characterization of the core NHEJ machinery over the past 20 years has been accompanied by elucidation of the genetic basis of several types of severe combined immunodeficiency (SCID) and a better understanding of the mechanisms regulating the choice between HR and NHEJ. In this chapter, we will therefore discuss the NHEJ mechanism along with considerations on DSB repair pathway choice and associated disease phenotypes.

AB - Repair of DNA double-strand breaks (DSBs) is indispensable for life. Therefore, most living organisms have at least two pathways to repair these breaks: homologous recombination (HR) and nonhomologous end-joining (NHEJ). HR is the main repair mode for replication-associated DSBs, while NHEJ deals with most other breaks, especially during the G0/G1 phase of the cell cycle. Characterization of the core NHEJ machinery over the past 20 years has been accompanied by elucidation of the genetic basis of several types of severe combined immunodeficiency (SCID) and a better understanding of the mechanisms regulating the choice between HR and NHEJ. In this chapter, we will therefore discuss the NHEJ mechanism along with considerations on DSB repair pathway choice and associated disease phenotypes.

UR - https://www.scopus.com/pages/publications/84960469177

U2 - 10.1007/978-4-431-55873-6_13

DO - 10.1007/978-4-431-55873-6_13

M3 - Chapter

SN - 9784431558712

SP - 341

EP - 362

BT - DNA Replication, Recombination, and Repair

PB - Springer Japan

CY - Japan

ER -

Nonhomologous End-Joining

Abstract

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