Nonthermal resection device for ablation of Barrett's esophagus: A feasibility and safety study

Annieke W. Gotink, Yonne Peters, Marco J. Bruno, Peter D. Siersema, Arjun D. Koch*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


Background Several techniques exist for the eradication of Barrett s esophagus (BE); however, all have limitations regarding successful conversion to squamous epithelium and a complication profile. We aimed to assess the feasibility and safety of a new nonthermal device, the EndoRotor, for the eradication of BE as a first-line ablation technique. Methods Patients with BE were prospectively included at two tertiary referral centers in The Netherlands. Inclusion criteria: BE length 2 5 cm, with low grade dysplasia, high grade dysplasia, or residual BE after endoscopic resection (ER) of a lesion containing early neoplasia. Exclusion criteria: previous ER >50% circumference, or previous ablation therapy. Follow-up endoscopywas performed 3 months after ab-comlation therapy. Outcomes were the percentage of endoscopically visible BE surface regression and complications. Results 30 patients were included (age 66 years, interquartile range [IQR] 59 73, median BE C0M3, 25 male). Overall, 18 patients underwent ER prior to ablation. Median percentage BE ablated was 100% (IQR 94% 100 %). Median visual BE surface regression at 3-month follow-up was 80% (IQR 68% 95 %). Multiple residual Barrett s islands were commonly seen. Six patients (20%) had a treatment-related complication requiring intervention, including one perforation (3 %), one postprocedural hemorrhage (3%), and four strictures (13%). Post-procedural pain was reported in 18 patients (60%). Conclusions Endoscopic ablation of BE using this novel nonthermal device was found to be technically demanding, with a longer procedure time compared with established ablation techniques and a high complication rate. Based on these results, we do not recommend its use as a first-line ablation technique for the eradication of BE.

Original languageEnglish
Pages (from-to)545-552
Number of pages8
Issue number6
Publication statusPublished - 21 Dec 2021

Bibliographical note

Funding Information:
M.J. Bruno: Consultant and lecture for Boston Scientific and Cook Medical. Research support from Boston Scientific, Cook Medical, 3 M, Pentax Medical, and InterScope. P.D. Siersema: Research support: Pentax – Japan, The E-Nose company – NL, MicroTech – China and Motus GI – USA. Advisory Board: Boston Scientific – USA and Motis GI – USA. The remaining Authors declare that there is no conflict of interest.

Funding Information:
This study was funded by Interscope Inc., Northbridge, MA, USA.

Publisher Copyright:
© 2022 Georg Thieme Verlag. All rights reserved.


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