Not all HLA epitope mismatches are equal

Sebastiaan Heidt; Frans H J Claas

doi:10.1016/j.kint.2019.12.017

Not all HLA epitope mismatches are equal

Sebastiaan Heidt^*
, Frans H J Claas

^*Corresponding author for this work

Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

Original language	English
Pages (from-to)	653-655
Number of pages	3
Journal	Kidney International
Volume	97
Issue number	4
DOIs	https://doi.org/10.1016/j.kint.2019.12.017
Publication status	Published - Apr 2020
Externally published	Yes

Bibliographical note

Access to Document

10.1016/j.kint.2019.12.017

Cite this

@article{6bc4759e0e604f1a8637c04cfa74d0a5,

title = "Not all HLA epitope mismatches are equal",

abstract = "The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.",

author = "Sebastiaan Heidt and Claas, \{Frans H J\}",

year = "2020",

month = apr,

doi = "10.1016/j.kint.2019.12.017",

language = "English",

volume = "97",

pages = "653--655",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Not all HLA epitope mismatches are equal

AU - Heidt, Sebastiaan

AU - Claas, Frans H J

PY - 2020/4

Y1 - 2020/4

N2 - The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

AB - The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

U2 - 10.1016/j.kint.2019.12.017

DO - 10.1016/j.kint.2019.12.017

M3 - Article

C2 - 32200859

SN - 0085-2538

VL - 97

SP - 653

EP - 655

JO - Kidney International

JF - Kidney International

IS - 4

ER -

Not all HLA epitope mismatches are equal

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this