Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J. M. Roks; Caroline Cheng; Catherine M. Shanahan

doi:10.1042/cs20210288

Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J. M. Roks^*, Caroline Cheng, Catherine M. Shanahan

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

2 Citations (Scopus)

Abstract

Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

Original language	English
Pages (from-to)	1209-1212
Number of pages	4
Journal	Clinical Science
Volume	135
Issue number	10
DOIs	https://doi.org/10.1042/cs20210288
Publication status	Published - 20 May 2021

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title = "Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease",

abstract = "Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.",

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AU - Roks, Anton J. M.

AU - Cheng, Caroline

AU - Shanahan, Catherine M.

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N2 - Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

AB - Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

U2 - 10.1042/cs20210288

DO - 10.1042/cs20210288

M3 - Editorial

SN - 0143-5221

VL - 135

SP - 1209

EP - 1212

JO - Clinical Science

JF - Clinical Science

IS - 10

ER -

Notch-Rho-cGMP interaction: common point of convergence in microvascular aging-related disease

Abstract

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