Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Elmira Mohammadi; Fatemeh Shafiee; Kiana Shahzamani; Mohammad Mehdi Ranjbar; Abbas Alibakhshi; Shahrzad Ahangarzadeh; Leila Beikmohammadi; Laleh Shariati; Soodeh Hooshmandi; Behrooz Ataei; Shaghayegh Haghjooy Javanmard

doi:10.1016/j.biopha.2021.111599

Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Elmira Mohammadi
, Fatemeh Shafiee
, Kiana Shahzamani
, Mohammad Mehdi Ranjbar
, Abbas Alibakhshi
, Shahrzad Ahangarzadeh^*
, Leila Beikmohammadi
, Laleh Shariati
, Soodeh Hooshmandi
, Behrooz Ataei
, Shaghayegh Haghjooy Javanmard

^*Corresponding author for this work

Biochemistry

Isfahan University of Medical Sciences
Agricultural Research, Education and Extension Organization (AREEO)
Hamedan University of Medical Sciences and Health Services
Erasmus University Rotterdam
Tehran University of Medical Sciences
Iran University of Medical Sciences

Research output: Contribution to journal › Review article › Academic › peer-review

35 Citations (Scopus)

196 Downloads (Pure)

Abstract

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

Original language	English
Article number	111599
Journal	Biomedicine and Pharmacotherapy
Volume	139
DOIs	https://doi.org/10.1016/j.biopha.2021.111599
Publication status	Published - Jul 2021

Bibliographical note

Funding Information:
The project was supported by Isfahan University of Medical Sciences [grant number: 198284 ]. The authors would like to thank infectious Diseases and Tropical Medicine Research Center for kind supports.

Publisher Copyright:
© 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.biopha.2021.111599

1-s2.0-S075333222100384X-mainLicence: CC BY-NC-ND

Cite this

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title = "Novel and emerging mutations of SARS-CoV-2: Biomedical implications",

abstract = "Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.",

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AU - Mohammadi, Elmira

AU - Shafiee, Fatemeh

AU - Shahzamani, Kiana

AU - Ranjbar, Mohammad Mehdi

AU - Alibakhshi, Abbas

AU - Ahangarzadeh, Shahrzad

AU - Beikmohammadi, Leila

AU - Shariati, Laleh

AU - Hooshmandi, Soodeh

AU - Ataei, Behrooz

AU - Javanmard, Shaghayegh Haghjooy

N1 - Funding Information: The project was supported by Isfahan University of Medical Sciences [grant number: 198284 ]. The authors would like to thank infectious Diseases and Tropical Medicine Research Center for kind supports. Publisher Copyright: © 2021

PY - 2021/7

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N2 - Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

AB - Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

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JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

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ER -

Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Abstract

Bibliographical note

UN SDGs

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