Abstract
Echocardiography is an important imaging modality widely utilised to assess the function of the heart’s pumping chambers, the left and right ventricle. In recent years, improvements in two- and three-dimensional image resolution alongside the development of analysis software, has facilitated a more detailed quantification of ventricular function. This thesis investigates the use of advanced, novel and emerging echocardiographic techniques for the assessment of right and left ventricular function in complex patient groups such as adult congenital heart disease and advanced left heart failure. The evaluation of these techniques is required in order to determine measurement feasibility, additional functional information and clinical value.
The assessment of right ventricular function using novel two-dimensional multi-plane echocardiography is evaluated in detail. With the ability to quantify regional wall function, it’s application is highly relevant in understanding right ventricular myocardial mechanics in patients with Tetralogy of Fallot. Advanced and novel parameters that quantify right ventricular function using two- and three-dimensional echocardiography are compared with those of cardiac magnetic resonance. Key differences in functional measurements are demonstrated, highlighting the continued need for multi-modality imaging in patients with adult congenital heart disease. In contrast to detailed quantification, novel solutions have been presented to evaluate cardiac function in patients with left ventricular assist devices whose standard echocardiographic views are very limited.
The research published within this thesis supports the implementation of advanced and novel echocardiographic techniques for the assessment of ventricular function in complex patient groups. It is anticipated that continued developments in ultrasound probe technology and software applications will help to ease their application into widespread clinical practice over the coming years.
The assessment of right ventricular function using novel two-dimensional multi-plane echocardiography is evaluated in detail. With the ability to quantify regional wall function, it’s application is highly relevant in understanding right ventricular myocardial mechanics in patients with Tetralogy of Fallot. Advanced and novel parameters that quantify right ventricular function using two- and three-dimensional echocardiography are compared with those of cardiac magnetic resonance. Key differences in functional measurements are demonstrated, highlighting the continued need for multi-modality imaging in patients with adult congenital heart disease. In contrast to detailed quantification, novel solutions have been presented to evaluate cardiac function in patients with left ventricular assist devices whose standard echocardiographic views are very limited.
The research published within this thesis supports the implementation of advanced and novel echocardiographic techniques for the assessment of ventricular function in complex patient groups. It is anticipated that continued developments in ultrasound probe technology and software applications will help to ease their application into widespread clinical practice over the coming years.
| Original language | English |
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| Award date | 2 Apr 2024 |
| Place of Publication | Rotterdam |
| Print ISBNs | 978-94-6483-683-7 |
| Publication status | Published - 2 Apr 2024 |