Novel mechanisms of salt-sensitive hypertension

Liffert Vogt, Francine Z. Marques, Toshiro Fujita, Ewout J. Hoorn, A. H.Jan Danser*

*Corresponding author for this work

Research output: Contribution to journalShort surveyPopular

11 Citations (Scopus)
79 Downloads (Pure)

Abstract

A high dietary sodium-consumption level is considered the most important lifestyle factor that can be modified to help prevent an increase in blood pressure and the development of hypertension. Despite numerous studies over the past decades, the pathophysiology explaining why some people show a salt-sensitive blood pressure response and others do not is incompletely understood. Here, a brief overview of the latest mechanistic insights is provided, focusing on the mononuclear phagocytic system and inflammation, the gut–kidney axis, and epigenetics. The article also discusses the effects of 3 types of novel drugs on salt-sensitive hypertension—sodium–glucose cotransporter 2 inhibitors, nonsteroidal mineralocorticoid receptor antagonists, and aldosterone synthase inhibitors. The conclusion is that besides kidney-centered mechanisms, vasoconstrictor mechanisms are also relevant for both the understanding and treatment of this blood pressure phenotype.

Original languageEnglish
Pages (from-to)690-697
Number of pages8
JournalKidney International
Volume104
Issue number4
Early online date13 Jul 2023
DOIs
Publication statusPublished - Oct 2023

Bibliographical note

Funding Information:
LV and EJH are supported by the Dutch Kidney Foundation (grant numbers 18OKG12 for LV and 21OK+013 for EJH). FZM is supported by a Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation , a National Heart Foundation Future Leader Fellowship (105663), and a National Health & Medical Research Council Emerging Leader Fellowship (GNT2017382).

Publisher Copyright:
© 2023

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