Nuclear proteins: finding and binding target sites in chromatin

Martin van Royen, A (Angelika) Zotter, SM (Shehu) Ibrahim, B (Bart) Geverts, Adriaan Houtsmuller

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Fluorescent protein labelling, as well as impressive progress in live cell imaging have revolutionised the view on how essential nuclear functions like gene transcription regulation and DNA repair are organised. Here, we address questions like how DNA-interacting molecules find and bind their target sequences in the vast amount of DNA. In addition, we discuss methods that have been developed for quantitative analysis of data from fluorescence recovery after photobleaching experiments (FRAP).
Original languageUndefined/Unknown
Pages (from-to)83-98
Number of pages16
JournalChromosome Research
Issue number1
Publication statusPublished - 2011

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  • EMC MM-03-24-01

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