Nucleic acid reference materials (NARMs): definitions and issues

DA Payne, CDS Mamotte, D Gancberg, M Pazzagli, Ron van Schaik, H Schimmel, F Rousseau

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Molecular diagnostics is one of the most rapidly growing areas of laboratory medicine. This rapid growth of clinical molecular tests has outpaced the availability and development of reference methods and reference materials. Such methods and materials are important for the development, validation, and interpretation of diagnostic methods and tests. Yet, there is a lack of harmonization between the numerous international organizations currently either certifying or defining reference materials. The objective of this position paper is to review and clarify the definition, attributes and applications for the use of reference materials in the context of molecular diagnostics. Clin Chem Lab Med 2010;48:1531-5.
Original languageUndefined/Unknown
Pages (from-to)1531-1535
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Issue number11
Publication statusPublished - 2010

Research programs

  • EMC MM-01-25-01

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