NUP98/11p15 translocations affect CD34+cells in myeloid and T lymphoid leukemias

B Crescenzi; V Nofrini; G Barba; C Matteucci; D Di Giacomo; P Gorello; Berna Beverloo; A Vitale; I Wlodarska; P Vandenberghe; R La Starza; C Mecucci

doi:10.1016/j.leukres.2015.04.014

NUP98/11p15 translocations affect CD34+cells in myeloid and T lymphoid leukemias

B Crescenzi, V Nofrini, G Barba, C Matteucci, D Di Giacomo, P Gorello, Berna Beverloo, A Vitale, I Wlodarska, P Vandenberghe, R La Starza, C Mecucci

Clinical Genetics

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T-lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. (C) 2015 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	769-772
Number of pages	4
Journal	Leukemia Research
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/j.leukres.2015.04.014
Publication status	Published - 2015

Research programs

EMC MGC-02-96-01

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10.1016/j.leukres.2015.04.014

Cite this

@article{ad5ca53dc8ca47c39e584a17437d6b9e,

title = "NUP98/11p15 translocations affect CD34+cells in myeloid and T lymphoid leukemias",

abstract = "We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T-lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. (C) 2015 Elsevier Ltd. All rights reserved.",

author = "B Crescenzi and V Nofrini and G Barba and C Matteucci and {Di Giacomo}, D and P Gorello and Berna Beverloo and A Vitale and I Wlodarska and P Vandenberghe and {La Starza}, R and C Mecucci",

year = "2015",

doi = "10.1016/j.leukres.2015.04.014",

language = "Undefined/Unknown",

volume = "39",

pages = "769--772",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "7",

}

TY - JOUR

T1 - NUP98/11p15 translocations affect CD34+cells in myeloid and T lymphoid leukemias

AU - Crescenzi, B

AU - Nofrini, V

AU - Barba, G

AU - Matteucci, C

AU - Di Giacomo, D

AU - Gorello, P

AU - Beverloo, Berna

AU - Vitale, A

AU - Wlodarska, I

AU - Vandenberghe, P

AU - La Starza, R

AU - Mecucci, C

PY - 2015

Y1 - 2015

N2 - We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T-lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. (C) 2015 Elsevier Ltd. All rights reserved.

AB - We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T-lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. (C) 2015 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.leukres.2015.04.014

DO - 10.1016/j.leukres.2015.04.014

M3 - Article

C2 - 26004809

SN - 0145-2126

VL - 39

SP - 769

EP - 772

JO - Leukemia Research

JF - Leukemia Research

IS - 7

ER -