Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

Hussein N. Yassine; Cécilia Samieri; Gill Livingston; Kimberly Glass; Maude Wagner; Christy Tangney; Brenda L. Plassman; M. Arfan Ikram; Robin M. Voigt; Yian Gu; Sid O'Bryant; Anne Marie Minihane; Suzanne Craft; Howard A. Fink; Suzanne Judd; Sandrine Andrieu; Gene L. Bowman; Edo Richard; Benedict Albensi; Emily Meyers; Serly Khosravian; Michele Solis; Maria Carrillo; Heather Snyder; Francine Grodstein; Nikolaos Scarmeas; Lon S. Schneider

doi:10.1016/S2666-7568(22)00120-9

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

Hussein N. Yassine^*
, Cécilia Samieri
, Gill Livingston
, Kimberly Glass
, Maude Wagner
, Christy Tangney
, Brenda L. Plassman
, M. Arfan Ikram
, Robin M. Voigt
, Yian Gu
, Sid O'Bryant
, Anne Marie Minihane
, Suzanne Craft
, Howard A. Fink
, Suzanne Judd
, Sandrine Andrieu
, Gene L. Bowman
, Edo Richard
, Benedict Albensi
, Emily Meyers

Serly Khosravian, Michele Solis, Maria Carrillo, Heather Snyder, Francine Grodstein, Nikolaos Scarmeas, Lon S. Schneider

^*Corresponding author for this work

Epidemiology

University of Southern California
Université de Bordeaux
University College London
Camden and Islington NHS Foundation Trust
Harvard Medical School
Hebrew SeniorLife
Harvard T.H. Chan School of Public Health
Rush Alzheimer’s Disease Center
Rush University
Duke University
Columbia University
University of North Texas Health Science Center
University of East Anglia
Wake Forest University School of Medicine
Department of Veterans Affairs
University of Alabama at Birmingham
Institut national de la santé et de la recherche médicale
Université Paul Sabatier Toulouse III
Oregon Health and Science University
National University of Natural Medicine
Radboud University Medical Center
Amsterdam UMC
Nova Southeastern University
University of Manitoba
National Alzheimer's Association
Keck School of Medicine of USC
National and Kapodistrian University of Athens Medical School

Research output: Contribution to journal › Review article › Academic › peer-review

95 Citations (Scopus)

90 Downloads (Pure)

Abstract

Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.

Original language	English
Pages (from-to)	e501-e512
Journal	The Lancet Healthy Longevity
Volume	3
Issue number	7
DOIs	https://doi.org/10.1016/S2666-7568(22)00120-9
Publication status	Published - 1 Jul 2022

Bibliographical note

Funding Information:
We thank Dr Kristina McLinden (National Institute on Aging, Bethesda, MD, USA), and Brianna Liu and Thomas Urich (Department of Medicine, University of Southern California, Los Angeles, CA, USA).

Funding Information:
This Personal View was supported by funding from both the National Institute on Aging (NIA; grant number R13AG069386) and the Alzheimer's Association. NS chairs and receives funding from the Albert Einstein College of Medicine Data Safety Monitoring Board. HNY is supported by the NIA (grant numbers: R21AG056518, R01AG055770, R01AG054434, R01AG067063, and RF1AG076124); is a principal investigator for NIA; and received honoraria from Huron Consulting firm. SJ receives funding from National Institutes of Health (NIH). SA receives funding from Nestec, and consultant fees from Roche as honororia for lectures. SC receives funding from NIH (grant number R01AG055122). MC receives funding from and is an employee of the Alzheimer's Association and has a child who attends graduate school at the University of Southern California. MS received funding from the Alzheimer's Association for help in preparing this manuscript; she also receives funding from the Lieber Institute for Brain Development Simons Foundation for Autism Research Initiative Nature, American Chemical Society, which paid for travel and meeting attendance in 2019. EM receives funding from and is an employee of the Alzheimer's Association. CT receives funding from NIA for diet and store prevention; the Alzheimer's Association for being part of the US Pointer study; UpToDate for being an author for cards on Nutritional antioxidants, and diets and supplements for lipid lowering; and Food and Nutrition Conference and Expo 2021 for providing lectures on nutrition and the brain (Women). GLB receives funding from NIH and NIA (grant number R01 AG043398) for a 3-year secondary prevention trial of omega-3 fatty acids for cerebral white matter lesions; GLB was also lead investigator on four issued patents owned by Nestle SA (international application numbers: PCT/EP2017/082148, PCT/EP2018/058701, PCT/EP2018/064813, and PCT/EP2017/065340); receives funding from a NIH/National Center on Complementary and Integrative Health training (grant number R90AT008924); was an advisor for the EU/USA Task Force on Clinical Trials in Alzheimer's Disease (unpaid) and Horizon 2020 EU-International research consortium PROPAG- AGEING (unpaid); and is co-founder, past co-chair and executive committee member of the Nutrition, Metabolism and Dementia professional interest area at the Alzheimer's Association ISTAART (unpaid). HS receives funding from the Alzheimer's Association and the NIH and is an employee of the Alzheimer's Association. LSS receives grants from Eli Lilly, Eisai, Roche/Genentech, Biogen, Novartis, Biohaven, Washington University Dominantly Inherited Alzheimer Network Trial Unit; and personal fees from Eli Lilly, Boehringer Ingelheim, Neurim, Cognition Therapeutics, Takeda, vTv Therapeutics, Roche/Genentech, Samus, Immunobrain Checkpoint, Cortexyme, AC Immune, Otsuka, GW Research, and Novo Nordisk. All other authors report no competing interests.

Publisher Copyright:
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., O'Bryant, S., Minihane, A. M., Craft, S., Fink, H. A., Judd, S., Andrieu, S., Bowman, G. L., Richard, E., Albensi, B., ... Schneider, L. S. (2022). Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. The Lancet Healthy Longevity, 3(7), e501-e512. https://doi.org/10.1016/S2666-7568(22)00120-9

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title = "Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group",

abstract = "Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.",

author = "Yassine, \{Hussein N.\} and C{\'e}cilia Samieri and Gill Livingston and Kimberly Glass and Maude Wagner and Christy Tangney and Plassman, \{Brenda L.\} and Ikram, \{M. Arfan\} and Voigt, \{Robin M.\} and Yian Gu and Sid O'Bryant and Minihane, \{Anne Marie\} and Suzanne Craft and Fink, \{Howard A.\} and Suzanne Judd and Sandrine Andrieu and Bowman, \{Gene L.\} and Edo Richard and Benedict Albensi and Emily Meyers and Serly Khosravian and Michele Solis and Maria Carrillo and Heather Snyder and Francine Grodstein and Nikolaos Scarmeas and Schneider, \{Lon S.\}",

note = "Funding Information: We thank Dr Kristina McLinden (National Institute on Aging, Bethesda, MD, USA), and Brianna Liu and Thomas Urich (Department of Medicine, University of Southern California, Los Angeles, CA, USA). Funding Information: This Personal View was supported by funding from both the National Institute on Aging (NIA; grant number R13AG069386) and the Alzheimer's Association. NS chairs and receives funding from the Albert Einstein College of Medicine Data Safety Monitoring Board. HNY is supported by the NIA (grant numbers: R21AG056518, R01AG055770, R01AG054434, R01AG067063, and RF1AG076124); is a principal investigator for NIA; and received honoraria from Huron Consulting firm. SJ receives funding from National Institutes of Health (NIH). SA receives funding from Nestec, and consultant fees from Roche as honororia for lectures. SC receives funding from NIH (grant number R01AG055122). MC receives funding from and is an employee of the Alzheimer's Association and has a child who attends graduate school at the University of Southern California. MS received funding from the Alzheimer's Association for help in preparing this manuscript; she also receives funding from the Lieber Institute for Brain Development Simons Foundation for Autism Research Initiative Nature, American Chemical Society, which paid for travel and meeting attendance in 2019. EM receives funding from and is an employee of the Alzheimer's Association. CT receives funding from NIA for diet and store prevention; the Alzheimer's Association for being part of the US Pointer study; UpToDate for being an author for cards on Nutritional antioxidants, and diets and supplements for lipid lowering; and Food and Nutrition Conference and Expo 2021 for providing lectures on nutrition and the brain (Women). GLB receives funding from NIH and NIA (grant number R01 AG043398) for a 3-year secondary prevention trial of omega-3 fatty acids for cerebral white matter lesions; GLB was also lead investigator on four issued patents owned by Nestle SA (international application numbers: PCT/EP2017/082148, PCT/EP2018/058701, PCT/EP2018/064813, and PCT/EP2017/065340); receives funding from a NIH/National Center on Complementary and Integrative Health training (grant number R90AT008924); was an advisor for the EU/USA Task Force on Clinical Trials in Alzheimer's Disease (unpaid) and Horizon 2020 EU-International research consortium PROPAG- AGEING (unpaid); and is co-founder, past co-chair and executive committee member of the Nutrition, Metabolism and Dementia professional interest area at the Alzheimer's Association ISTAART (unpaid). HS receives funding from the Alzheimer's Association and the NIH and is an employee of the Alzheimer's Association. LSS receives grants from Eli Lilly, Eisai, Roche/Genentech, Biogen, Novartis, Biohaven, Washington University Dominantly Inherited Alzheimer Network Trial Unit; and personal fees from Eli Lilly, Boehringer Ingelheim, Neurim, Cognition Therapeutics, Takeda, vTv Therapeutics, Roche/Genentech, Samus, Immunobrain Checkpoint, Cortexyme, AC Immune, Otsuka, GW Research, and Novo Nordisk. All other authors report no competing interests. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",

year = "2022",

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doi = "10.1016/S2666-7568(22)00120-9",

language = "English",

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Yassine, HN, Samieri, C, Livingston, G, Glass, K, Wagner, M, Tangney, C, Plassman, BL, Ikram, MA, Voigt, RM, Gu, Y, O'Bryant, S, Minihane, AM, Craft, S, Fink, HA, Judd, S, Andrieu, S, Bowman, GL, Richard, E, Albensi, B, Meyers, E, Khosravian, S, Solis, M, Carrillo, M, Snyder, H, Grodstein, F, Scarmeas, N & Schneider, LS 2022, 'Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group', The Lancet Healthy Longevity, vol. 3, no. 7, pp. e501-e512. https://doi.org/10.1016/S2666-7568(22)00120-9

TY - JOUR

T1 - Nutrition state of science and dementia prevention

T2 - recommendations of the Nutrition for Dementia Prevention Working Group

AU - Yassine, Hussein N.

AU - Samieri, Cécilia

AU - Livingston, Gill

AU - Glass, Kimberly

AU - Wagner, Maude

AU - Tangney, Christy

AU - Plassman, Brenda L.

AU - Ikram, M. Arfan

AU - Voigt, Robin M.

AU - Gu, Yian

AU - O'Bryant, Sid

AU - Minihane, Anne Marie

AU - Craft, Suzanne

AU - Fink, Howard A.

AU - Judd, Suzanne

AU - Andrieu, Sandrine

AU - Bowman, Gene L.

AU - Richard, Edo

AU - Albensi, Benedict

AU - Meyers, Emily

AU - Khosravian, Serly

AU - Solis, Michele

AU - Carrillo, Maria

AU - Snyder, Heather

AU - Grodstein, Francine

AU - Scarmeas, Nikolaos

AU - Schneider, Lon S.

N1 - Funding Information: We thank Dr Kristina McLinden (National Institute on Aging, Bethesda, MD, USA), and Brianna Liu and Thomas Urich (Department of Medicine, University of Southern California, Los Angeles, CA, USA). Funding Information: This Personal View was supported by funding from both the National Institute on Aging (NIA; grant number R13AG069386) and the Alzheimer's Association. NS chairs and receives funding from the Albert Einstein College of Medicine Data Safety Monitoring Board. HNY is supported by the NIA (grant numbers: R21AG056518, R01AG055770, R01AG054434, R01AG067063, and RF1AG076124); is a principal investigator for NIA; and received honoraria from Huron Consulting firm. SJ receives funding from National Institutes of Health (NIH). SA receives funding from Nestec, and consultant fees from Roche as honororia for lectures. SC receives funding from NIH (grant number R01AG055122). MC receives funding from and is an employee of the Alzheimer's Association and has a child who attends graduate school at the University of Southern California. MS received funding from the Alzheimer's Association for help in preparing this manuscript; she also receives funding from the Lieber Institute for Brain Development Simons Foundation for Autism Research Initiative Nature, American Chemical Society, which paid for travel and meeting attendance in 2019. EM receives funding from and is an employee of the Alzheimer's Association. CT receives funding from NIA for diet and store prevention; the Alzheimer's Association for being part of the US Pointer study; UpToDate for being an author for cards on Nutritional antioxidants, and diets and supplements for lipid lowering; and Food and Nutrition Conference and Expo 2021 for providing lectures on nutrition and the brain (Women). GLB receives funding from NIH and NIA (grant number R01 AG043398) for a 3-year secondary prevention trial of omega-3 fatty acids for cerebral white matter lesions; GLB was also lead investigator on four issued patents owned by Nestle SA (international application numbers: PCT/EP2017/082148, PCT/EP2018/058701, PCT/EP2018/064813, and PCT/EP2017/065340); receives funding from a NIH/National Center on Complementary and Integrative Health training (grant number R90AT008924); was an advisor for the EU/USA Task Force on Clinical Trials in Alzheimer's Disease (unpaid) and Horizon 2020 EU-International research consortium PROPAG- AGEING (unpaid); and is co-founder, past co-chair and executive committee member of the Nutrition, Metabolism and Dementia professional interest area at the Alzheimer's Association ISTAART (unpaid). HS receives funding from the Alzheimer's Association and the NIH and is an employee of the Alzheimer's Association. LSS receives grants from Eli Lilly, Eisai, Roche/Genentech, Biogen, Novartis, Biohaven, Washington University Dominantly Inherited Alzheimer Network Trial Unit; and personal fees from Eli Lilly, Boehringer Ingelheim, Neurim, Cognition Therapeutics, Takeda, vTv Therapeutics, Roche/Genentech, Samus, Immunobrain Checkpoint, Cortexyme, AC Immune, Otsuka, GW Research, and Novo Nordisk. All other authors report no competing interests. Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.

AB - Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.

UR - https://www.scopus.com/pages/publications/85133250910

U2 - 10.1016/S2666-7568(22)00120-9

DO - 10.1016/S2666-7568(22)00120-9

M3 - Review article

AN - SCOPUS:85133250910

SN - 2666-7568

VL - 3

SP - e501-e512

JO - The Lancet Healthy Longevity

JF - The Lancet Healthy Longevity

IS - 7

ER -

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group

Abstract

Bibliographical note

UN SDGs

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