TY - JOUR
T1 - Objective assessment of olfactory function using functional magnetic resonance imaging
AU - Toledano, Adolfo
AU - Borromeo, Susana
AU - Luna, Guillermo
AU - Molina, Elena
AU - Beatriz Solana, Ana
AU - Garcia-Polo, Pablo
AU - Antonio Hernandez, Juan
AU - Alvarez-linera, Juan
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To show the results of a device that generates automated olfactory stimuli suitable for functional magnetic resonance imaging (fMRI) experiments.Material and methods: Ten normal volunteers, 5 women and 5 men, were studied. The system allows the programming of several sequences, providing the capability to synchronise the onset of odour presentation with acquisition by a trigger signal of the MRI scanner. The olfactometer is a device that allows selection of the odour, the event paradigm, the time of stimuli and the odour concentration. The paradigm used during fMRI scanning consisted of 15-s blocks. The odorant event took 2 s with butanol, mint and coffee.Results: We observed olfactory activity in the olfactory bulb, entorhinal cortex (4%), amygdala (2.5%) and temporo-parietal cortex, especially in the areas related to emotional integration.Conclusions: The device has demonstrated its effectiveness in stimulating olfactory areas and its capacity to adapt to fMRI equipment. (C) 2010 Elsevier Espana, S.L. All rights reserved.
AB - Objective: To show the results of a device that generates automated olfactory stimuli suitable for functional magnetic resonance imaging (fMRI) experiments.Material and methods: Ten normal volunteers, 5 women and 5 men, were studied. The system allows the programming of several sequences, providing the capability to synchronise the onset of odour presentation with acquisition by a trigger signal of the MRI scanner. The olfactometer is a device that allows selection of the odour, the event paradigm, the time of stimuli and the odour concentration. The paradigm used during fMRI scanning consisted of 15-s blocks. The odorant event took 2 s with butanol, mint and coffee.Results: We observed olfactory activity in the olfactory bulb, entorhinal cortex (4%), amygdala (2.5%) and temporo-parietal cortex, especially in the areas related to emotional integration.Conclusions: The device has demonstrated its effectiveness in stimulating olfactory areas and its capacity to adapt to fMRI equipment. (C) 2010 Elsevier Espana, S.L. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=84864016016&partnerID=8YFLogxK
U2 - 10.1016/j.otorri.2012.01.010
DO - 10.1016/j.otorri.2012.01.010
M3 - Article
C2 - 22487600
AN - SCOPUS:84864016016
SN - 0001-6519
VL - 63
SP - 280
EP - 285
JO - Acta Otorrinolaringologica Espanola
JF - Acta Otorrinolaringologica Espanola
IS - 4
ER -