Objective assessment of olfactory function using functional magnetic resonance imaging (fMRI)

Susana Borromeo*, J. A. Hernández-Tamames, Guillermo Luna, Felipe MacHado, Norberto Malpica, Adolfo Toledano

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Impairment of the olfactory sensibility can be an indicator of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The problem lies in obtaining an objective quantitative analysis of olfactory response. For this task, we will use functional magnetic resonance imaging (fMRI) and a device that will provide a selective and controlled stimulation of the olfactory system. The novel issues of our design are synchronization between the acquisition and the olfactory task, and automated control of experimental parameters, odorants sequences, and frequency. We present a review of the basic fMRI experimental design of event-related stimulus paradigms versus block design experiments, and their use in olfactory experiments. Finally, we present the preliminary results obtained on a real 3-T magnetic resonance imaging (MRI) scanner.

Original languageEnglish
Article number5560820
Pages (from-to)2602-2608
Number of pages7
JournalIEEE Transactions on Instrumentation and Measurement
Volume59
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Bibliographical note

Funding Information:
Manuscript received July 20, 2009; revised October 19, 2009; accepted October 20, 2009. Date of current version September 15, 2010. This work was supported by the OLFACTOSENSE Network under Grant CAM-S-SEM-0255-2006 from Comunidad Autónoma de Madrid. The Associate Editor coordinating the review process for this paper was Domenico Grimaldi.

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