Abstract
Impairment of the olfactory sensibility can be an indicator of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The problem lies in obtaining an objective quantitative analysis of olfactory response. For this task, we will use functional magnetic resonance imaging (fMRI) and a device that will provide a selective and controlled stimulation of the olfactory system. The novel issues of our design are synchronization between the acquisition and the olfactory task, and automated control of experimental parameters, odorants sequences, and frequency. We present a review of the basic fMRI experimental design of event-related stimulus paradigms versus block design experiments, and their use in olfactory experiments. Finally, we present the preliminary results obtained on a real 3-T magnetic resonance imaging (MRI) scanner.
| Original language | English |
|---|---|
| Article number | 5560820 |
| Pages (from-to) | 2602-2608 |
| Number of pages | 7 |
| Journal | IEEE Transactions on Instrumentation and Measurement |
| Volume | 59 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2010 |
| Externally published | Yes |
Bibliographical note
Funding Information:Manuscript received July 20, 2009; revised October 19, 2009; accepted October 20, 2009. Date of current version September 15, 2010. This work was supported by the OLFACTOSENSE Network under Grant CAM-S-SEM-0255-2006 from Comunidad Autónoma de Madrid. The Associate Editor coordinating the review process for this paper was Domenico Grimaldi.