Obstructive sleep apnea in children with syndromic craniosynostosis: long-term respiratory outcome of midface advancement

Natalja Bannink, Erik Nout, Eppo Wolvius, Hans Hoeve, Koen Joosten, Irene Mathijssen

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)


Almost 50% of patients with Apert, Crouzon or Pfeiffer syndrome develop obstructive sleep apnea (OSA), mainly due to midface hypoplasia. Midface advancement is often the treatment of choice, but the few papers on long-term outcome report mixed results. This paper aimed to assess the long-term respiratory outcome of midface advancement in syndromic craniosynostosis with OSA and to determine factors contributing to its efficacy. A retrospective Study was performed on 11 patients with moderate or severe OSA, requiring oxygen, continuous positive airway pressure (CPAP), or tracheostomy. Clinical symptoms, results of polysomnography, endoscopy and digital volume measurement Of the upper airways oil CT scan before and after midface advancement were reviewed. Midface advancement had a good respiratory outcome in the short term in 6 patients and was ineffective in 5. In all patients without respiratory effect or with relapse, endoscopy showed obstruction of the rhino- or hypopharynx. The volume measurements supported the clinical and endoscopic outcome. Despite midface advancement, long-term dependence on, or indication for, CPAP or tracheostomy was maintained in 5 of 11 patients. Pharyngeal collapse appeared to play a role in OSA. Endoscopy before midface advancement is recommended to identify airway obstruction that may interfere with respiratory improvement after midface advancement.
Original languageUndefined/Unknown
Pages (from-to)115-121
Number of pages7
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number2
Publication statusPublished - 2010

Cite this