Steven W.J. Lamberts*, Aart-Jan van der Lely, Wouter W. de Herder, Leo J. Hofland

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

896 Citations (Scopus)


A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats. This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids. Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion. Today, somatostatin is best regarded as a phylogenetically ancient, multigene family of peptides with two important bioactive products: somatostatin-14 and somatostatin-28, the latter a congener of somatostatin-14 extended at the N-terminal.
Original languageEnglish
Pages (from-to)246-254
JournalThe New England journal of medicine
Issue number4
Publication statusPublished - 25 Jan 1996

Bibliographical note

Copyright © 1996 Massachusetts Medical Society. All rights reserved.


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