TY - JOUR
T1 - Octreotide
AU - Lamberts, Steven W.J.
AU - van der Lely, Aart-Jan
AU - de Herder, Wouter W.
AU - Hofland, Leo J.
N1 - Copyright © 1996 Massachusetts Medical Society. All rights reserved.
PY - 1996/1/25
Y1 - 1996/1/25
N2 - A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats. This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids. Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion. Today, somatostatin is best regarded as a phylogenetically ancient, multigene family of peptides with two important bioactive products: somatostatin-14 and somatostatin-28, the latter a congener of somatostatin-14 extended at the N-terminal.
AB - A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats. This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids. Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion. Today, somatostatin is best regarded as a phylogenetically ancient, multigene family of peptides with two important bioactive products: somatostatin-14 and somatostatin-28, the latter a congener of somatostatin-14 extended at the N-terminal.
U2 - 10.1056/NEJM199601253340408
DO - 10.1056/NEJM199601253340408
M3 - Article
C2 - 8532003
SN - 0028-4793
VL - 334
SP - 246
EP - 254
JO - The New England journal of medicine
JF - The New England journal of medicine
IS - 4
ER -