Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

Frank Qian; Nathan Tintle; Fatty Acids and Outcomes Research Consortium (FORCE); Paul N. Jensen; Rozenn N. Lemaitre; Fumiaki Imamura; Tobias Rudholm Feldreich; Sarah Oppeneer Nomura; Weihua Guan; Federica Laguzzi; Eunjung Kim; Jyrki K. Virtanen; Marinka Steur; Christian S. Bork; Yoichiro Hirakawa; Michelle L. O'Donoghue; Aleix Sala-Vila; Andres V. Ardisson Korat; Qi Sun; Eric B. Rimm; Bruce M. Psaty; Susan R. Heckbert; Nita G. Forouhi; Nicholas J. Wareham; Matti Marklund; Ulf Risérus; Lars Lind; Johan Ärnlöv; Parveen Garg; Michael Y. Tsai; James Pankow; Jeffrey R. Misialek; Bruna Gigante; Karin Leander; Julie A. Pester; Christine M. Albert; Maryam Kavousi; Arfan Ikram; Trudy Voortman; Erik B. Schmidt; Toshiharu Ninomiya; David A. Morrow; Antoni Bayés-Genís; James H. O'Keefe; Kwok Leung Ong; Jason H.Y. Wu; Dariush Mozaffarian; William S. Harris; David S. Siscovick

doi:10.1016/j.jacc.2023.05.024

Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

Frank Qian, Nathan Tintle, Fatty Acids and Outcomes Research Consortium (FORCE), Paul N. Jensen, Rozenn N. Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K. Virtanen, Marinka Steur, Christian S. Bork, Yoichiro Hirakawa, Michelle L. O'Donoghue, Aleix Sala-Vila, Andres V. Ardisson Korat, Qi Sun, Eric B. RimmBruce M. Psaty, Susan R. Heckbert, Nita G. Forouhi, Nicholas J. Wareham, Matti Marklund, Ulf Risérus, Lars Lind, Johan Ärnlöv, Parveen Garg, Michael Y. Tsai, James Pankow, Jeffrey R. Misialek, Bruna Gigante, Karin Leander, Julie A. Pester, Christine M. Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B. Schmidt, Toshiharu Ninomiya, David A. Morrow, Antoni Bayés-Genís, James H. O'Keefe, Kwok Leung Ong, Jason H.Y. Wu, Dariush Mozaffarian, William S. Harris, David S. Siscovick^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. Conclusions: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.

Original language	English
Pages (from-to)	336-349
Number of pages	14
Journal	Journal of the American College of Cardiology
Volume	82
Issue number	4
DOIs	https://doi.org/10.1016/j.jacc.2023.05.024
Publication status	Published - 25 Jul 2023

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Publisher Copyright:
© 2023 American College of Cardiology Foundation

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10.1016/j.jacc.2023.05.024

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Qian, F., Tintle, N., Fatty Acids and Outcomes Research Consortium (FORCE), Jensen, P. N., Lemaitre, R. N., Imamura, F., Feldreich, T. R., Nomura, S. O., Guan, W., Laguzzi, F., Kim, E., Virtanen, J. K., Steur, M., Bork, C. S., Hirakawa, Y., O'Donoghue, M. L., Sala-Vila, A., Ardisson Korat, A. V., Sun, Q., ... Siscovick, D. S. (2023). Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. Journal of the American College of Cardiology, 82(4), 336-349. https://doi.org/10.1016/j.jacc.2023.05.024

@article{fe57f1014619468e8a6a6617419f66ef,

title = "Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation",

abstract = "Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. Conclusions: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.",

author = "Frank Qian and Nathan Tintle and {Fatty Acids and Outcomes Research Consortium (FORCE)} and Jensen, {Paul N.} and Lemaitre, {Rozenn N.} and Fumiaki Imamura and Feldreich, {Tobias Rudholm} and Nomura, {Sarah Oppeneer} and Weihua Guan and Federica Laguzzi and Eunjung Kim and Virtanen, {Jyrki K.} and Marinka Steur and Bork, {Christian S.} and Yoichiro Hirakawa and O'Donoghue, {Michelle L.} and Aleix Sala-Vila and {Ardisson Korat}, {Andres V.} and Qi Sun and Rimm, {Eric B.} and Psaty, {Bruce M.} and Heckbert, {Susan R.} and Forouhi, {Nita G.} and Wareham, {Nicholas J.} and Matti Marklund and Ulf Ris{\'e}rus and Lars Lind and Johan {\"A}rnl{\"o}v and Parveen Garg and Tsai, {Michael Y.} and James Pankow and Misialek, {Jeffrey R.} and Bruna Gigante and Karin Leander and Pester, {Julie A.} and Albert, {Christine M.} and Maryam Kavousi and Arfan Ikram and Trudy Voortman and Schmidt, {Erik B.} and Toshiharu Ninomiya and Morrow, {David A.} and Antoni Bay{\'e}s-Gen{\'i}s and O'Keefe, {James H.} and Ong, {Kwok Leung} and Wu, {Jason H.Y.} and Dariush Mozaffarian and Harris, {William S.} and Siscovick, {David S.}",

note = "Publisher Copyright: {\textcopyright} 2023 American College of Cardiology Foundation",

year = "2023",

month = jul,

day = "25",

doi = "10.1016/j.jacc.2023.05.024",

language = "English",

volume = "82",

pages = "336--349",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier Inc.",

number = "4",

}

Qian, F, Tintle, N, Fatty Acids and Outcomes Research Consortium (FORCE), Jensen, PN, Lemaitre, RN, Imamura, F, Feldreich, TR, Nomura, SO, Guan, W, Laguzzi, F, Kim, E, Virtanen, JK, Steur, M, Bork, CS, Hirakawa, Y, O'Donoghue, ML, Sala-Vila, A, Ardisson Korat, AV, Sun, Q, Rimm, EB, Psaty, BM, Heckbert, SR, Forouhi, NG, Wareham, NJ, Marklund, M, Risérus, U, Lind, L, Ärnlöv, J, Garg, P, Tsai, MY, Pankow, J, Misialek, JR, Gigante, B, Leander, K, Pester, JA, Albert, CM, Kavousi, M , Ikram, A , Voortman, T, Schmidt, EB, Ninomiya, T, Morrow, DA, Bayés-Genís, A, O'Keefe, JH, Ong, KL, Wu, JHY, Mozaffarian, D, Harris, WS & Siscovick, DS 2023, 'Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation', Journal of the American College of Cardiology, vol. 82, no. 4, pp. 336-349. https://doi.org/10.1016/j.jacc.2023.05.024

TY - JOUR

T1 - Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

AU - Qian, Frank

AU - Tintle, Nathan

AU - Fatty Acids and Outcomes Research Consortium (FORCE)

AU - Jensen, Paul N.

AU - Lemaitre, Rozenn N.

AU - Imamura, Fumiaki

AU - Feldreich, Tobias Rudholm

AU - Nomura, Sarah Oppeneer

AU - Guan, Weihua

AU - Laguzzi, Federica

AU - Kim, Eunjung

AU - Virtanen, Jyrki K.

AU - Steur, Marinka

AU - Bork, Christian S.

AU - Hirakawa, Yoichiro

AU - O'Donoghue, Michelle L.

AU - Sala-Vila, Aleix

AU - Ardisson Korat, Andres V.

AU - Sun, Qi

AU - Rimm, Eric B.

AU - Psaty, Bruce M.

AU - Heckbert, Susan R.

AU - Forouhi, Nita G.

AU - Wareham, Nicholas J.

AU - Marklund, Matti

AU - Risérus, Ulf

AU - Lind, Lars

AU - Ärnlöv, Johan

AU - Garg, Parveen

AU - Tsai, Michael Y.

AU - Pankow, James

AU - Misialek, Jeffrey R.

AU - Gigante, Bruna

AU - Leander, Karin

AU - Pester, Julie A.

AU - Albert, Christine M.

AU - Kavousi, Maryam

AU - Ikram, Arfan

AU - Voortman, Trudy

AU - Schmidt, Erik B.

AU - Ninomiya, Toshiharu

AU - Morrow, David A.

AU - Bayés-Genís, Antoni

AU - O'Keefe, James H.

AU - Ong, Kwok Leung

AU - Wu, Jason H.Y.

AU - Mozaffarian, Dariush

AU - Harris, William S.

AU - Siscovick, David S.

PY - 2023/7/25

Y1 - 2023/7/25

N2 - Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. Conclusions: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.

AB - Background: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. Objectives: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. Methods: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. Results: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. Conclusions: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.

UR - http://www.scopus.com/inward/record.url?scp=85164507680&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2023.05.024

DO - 10.1016/j.jacc.2023.05.024

M3 - Article

C2 - 37468189

AN - SCOPUS:85164507680

SN - 0735-1097

VL - 82

SP - 336

EP - 349

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 4

ER -

Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

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