Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma

J Bauer, Emine Kiliç, Jolanda Vaarwater, BC Bastian, C Garbe, Annelies de Klein

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87 Citations (Scopus)

Abstract

BACKGROUND: Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and in the blue nevi of the skin. METHODS: GNAQ exon 5 was amplified from 75 ciliary body and choroidal melanoma DNAs and sequenced directly. GNAQ mutation status was correlated with disease-free survival (DFS), as well as other clinical and histopathological factors, and with chromosomal variations detected by FISH and CGH. RESULTS: Of the 75 tumour DNA samples analysed, 40 (53.3%) harboured oncogenic mutations in GNAQ codon 209. Univariate and multivariate analysis showed that GNAQ mutation status was not significantly correlated with DFS. CONCLUSION: The GNAQ mutation status is not suitable to predict DFS. However, the high frequency of GNAQ mutations may render it a promising target for therapeutic intervention. British Journal of Cancer ( 2009) 101, 813-815. doi:10.1038/sj.bjc.6605226 www.bjcancer.com Published online 4 August 2009 (C) 2009 Cancer Research UK
Original languageUndefined/Unknown
Pages (from-to)813-815
Number of pages3
JournalBritish Journal of Cancer
Volume101
Issue number5
DOIs
Publication statusPublished - 2009

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