ONCOR: design of the Dutch cardio-oncology registry

J. A.M. Kamphuis; M. Linschoten; M. J. Cramer; F. Alsemgeest; D. J.W. van Kessel; K. Urgel; M. C. Post; O. C. Manintveld; H. C. Hassing; C. Liesting; A. J. Wardeh; E. G.M. Olde Bijvank; J. Schaap; A. M. Stevense-den Boer; P. A. Doevendans; F. W. Asselbergs; A. J. Teske

doi:10.1007/s12471-020-01517-8

ONCOR: design of the Dutch cardio-oncology registry

J. A.M. Kamphuis, M. Linschoten, M. J. Cramer, F. Alsemgeest, D. J.W. van Kessel, K. Urgel, M. C. Post, O. C. Manintveld, H. C. Hassing, C. Liesting, A. J. Wardeh, E. G.M. Olde Bijvank, J. Schaap, A. M. Stevense-den Boer, P. A. Doevendans, F. W. Asselbergs, A. J. Teske^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The relative new subspecialty ‘cardio-oncology’ was established to meet the growing demand for an interdisciplinary approach to the management of cancer therapy–related cardiovascular adverse events. In recent years, specialised cardio-oncology services have been implemented worldwide, which all strive to improve the cardiovascular health of cancer patients. However, limited data are currently available on the outcomes and experiences of these specialised services, and optimal strategies for cardio-oncological care have not been established. Aim: The ONCOR registry has been created for prospective data collection and evaluation of cardio-oncological care in daily practice. Methods: Dutch hospitals using a standardised cardio-oncology care pathway are included in this national, multicentre, observational cohort study. All patients visiting these cardio-oncology services are eligible for study inclusion. Data collection at baseline consists of the (planned) cancer treatment and the cardiovascular risk profile, which are used to estimate the cardiotoxic risk. Information regarding invasive and noninvasive tests is collected during the time patients receive cardio-oncological care. Outcome data consist of the incidence of cardiovascular complications and major adverse cardiac events, and the impact of these events on the oncological treatment. Discussion: Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy–related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate.

Original language	English
Pages (from-to)	288-294
Number of pages	7
Journal	Netherlands Heart Journal
Volume	29
Issue number	5
Early online date	17 Nov 2020
DOIs	https://doi.org/10.1007/s12471-020-01517-8
Publication status	Published - May 2021

Bibliographical note

Funding Information:
We acknowledge the support from the Netherlands Heart Institute (W. Hermans-van Ast and E.P.A. van Iperen).

Funding Information:
M. Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W. Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre.

Funding Information:
We acknowledge the support from the Netherlands Heart Institute (W.?Hermans-van Ast and E.P.A.?van Iperen). M.?Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W.?Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre.

Publisher Copyright:
© 2020, The Author(s).

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Cite this

Kamphuis, J. A. M., Linschoten, M., Cramer, M. J., Alsemgeest, F., van Kessel, D. J. W., Urgel, K., Post, M. C., Manintveld, O. C., Hassing, H. C., Liesting, C., Wardeh, A. J., Olde Bijvank, E. G. M., Schaap, J., Stevense-den Boer, A. M., Doevendans, P. A., Asselbergs, F. W., & Teske, A. J. (2021). ONCOR: design of the Dutch cardio-oncology registry. Netherlands Heart Journal, 29(5), 288-294. https://doi.org/10.1007/s12471-020-01517-8

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title = "ONCOR: design of the Dutch cardio-oncology registry",

abstract = "Background: The relative new subspecialty {\textquoteleft}cardio-oncology{\textquoteright} was established to meet the growing demand for an interdisciplinary approach to the management of cancer therapy–related cardiovascular adverse events. In recent years, specialised cardio-oncology services have been implemented worldwide, which all strive to improve the cardiovascular health of cancer patients. However, limited data are currently available on the outcomes and experiences of these specialised services, and optimal strategies for cardio-oncological care have not been established. Aim: The ONCOR registry has been created for prospective data collection and evaluation of cardio-oncological care in daily practice. Methods: Dutch hospitals using a standardised cardio-oncology care pathway are included in this national, multicentre, observational cohort study. All patients visiting these cardio-oncology services are eligible for study inclusion. Data collection at baseline consists of the (planned) cancer treatment and the cardiovascular risk profile, which are used to estimate the cardiotoxic risk. Information regarding invasive and noninvasive tests is collected during the time patients receive cardio-oncological care. Outcome data consist of the incidence of cardiovascular complications and major adverse cardiac events, and the impact of these events on the oncological treatment. Discussion: Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy–related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate.",

author = "Kamphuis, {J. A.M.} and M. Linschoten and Cramer, {M. J.} and F. Alsemgeest and {van Kessel}, {D. J.W.} and K. Urgel and Post, {M. C.} and Manintveld, {O. C.} and Hassing, {H. C.} and C. Liesting and Wardeh, {A. J.} and {Olde Bijvank}, {E. G.M.} and J. Schaap and {Stevense-den Boer}, {A. M.} and Doevendans, {P. A.} and Asselbergs, {F. W.} and Teske, {A. J.}",

note = "Funding Information: We acknowledge the support from the Netherlands Heart Institute (W. Hermans-van Ast and E.P.A. van Iperen). Funding Information: M. Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W. Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre. Funding Information: We acknowledge the support from the Netherlands Heart Institute (W.?Hermans-van Ast and E.P.A.?van Iperen). M.?Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W.?Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2021",

month = may,

doi = "10.1007/s12471-020-01517-8",

language = "English",

volume = "29",

pages = "288--294",

journal = "Netherlands Heart Journal",

issn = "1568-5888",

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}

Kamphuis, JAM, Linschoten, M, Cramer, MJ, Alsemgeest, F, van Kessel, DJW, Urgel, K, Post, MC, Manintveld, OC, Hassing, HC, Liesting, C, Wardeh, AJ, Olde Bijvank, EGM, Schaap, J, Stevense-den Boer, AM, Doevendans, PA, Asselbergs, FW & Teske, AJ 2021, 'ONCOR: design of the Dutch cardio-oncology registry', Netherlands Heart Journal, vol. 29, no. 5, pp. 288-294. https://doi.org/10.1007/s12471-020-01517-8

TY - JOUR

T1 - ONCOR

T2 - design of the Dutch cardio-oncology registry

AU - Kamphuis, J. A.M.

AU - Linschoten, M.

AU - Cramer, M. J.

AU - Alsemgeest, F.

AU - van Kessel, D. J.W.

AU - Urgel, K.

AU - Post, M. C.

AU - Manintveld, O. C.

AU - Hassing, H. C.

AU - Liesting, C.

AU - Wardeh, A. J.

AU - Olde Bijvank, E. G.M.

AU - Schaap, J.

AU - Stevense-den Boer, A. M.

AU - Doevendans, P. A.

AU - Asselbergs, F. W.

AU - Teske, A. J.

N1 - Funding Information: We acknowledge the support from the Netherlands Heart Institute (W. Hermans-van Ast and E.P.A. van Iperen). Funding Information: M. Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W. Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre. Funding Information: We acknowledge the support from the Netherlands Heart Institute (W.?Hermans-van Ast and E.P.A.?van Iperen). M.?Linschoten has received support from the Alexandre Suerman Stipend of the University Medical Centre Utrecht. F.W.?Asselbergs has received support from the University College London Hospitals, National Institute for Health Research Biomedical Research Centre. Publisher Copyright: © 2020, The Author(s).

PY - 2021/5

Y1 - 2021/5

N2 - Background: The relative new subspecialty ‘cardio-oncology’ was established to meet the growing demand for an interdisciplinary approach to the management of cancer therapy–related cardiovascular adverse events. In recent years, specialised cardio-oncology services have been implemented worldwide, which all strive to improve the cardiovascular health of cancer patients. However, limited data are currently available on the outcomes and experiences of these specialised services, and optimal strategies for cardio-oncological care have not been established. Aim: The ONCOR registry has been created for prospective data collection and evaluation of cardio-oncological care in daily practice. Methods: Dutch hospitals using a standardised cardio-oncology care pathway are included in this national, multicentre, observational cohort study. All patients visiting these cardio-oncology services are eligible for study inclusion. Data collection at baseline consists of the (planned) cancer treatment and the cardiovascular risk profile, which are used to estimate the cardiotoxic risk. Information regarding invasive and noninvasive tests is collected during the time patients receive cardio-oncological care. Outcome data consist of the incidence of cardiovascular complications and major adverse cardiac events, and the impact of these events on the oncological treatment. Discussion: Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy–related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate.

AB - Background: The relative new subspecialty ‘cardio-oncology’ was established to meet the growing demand for an interdisciplinary approach to the management of cancer therapy–related cardiovascular adverse events. In recent years, specialised cardio-oncology services have been implemented worldwide, which all strive to improve the cardiovascular health of cancer patients. However, limited data are currently available on the outcomes and experiences of these specialised services, and optimal strategies for cardio-oncological care have not been established. Aim: The ONCOR registry has been created for prospective data collection and evaluation of cardio-oncological care in daily practice. Methods: Dutch hospitals using a standardised cardio-oncology care pathway are included in this national, multicentre, observational cohort study. All patients visiting these cardio-oncology services are eligible for study inclusion. Data collection at baseline consists of the (planned) cancer treatment and the cardiovascular risk profile, which are used to estimate the cardiotoxic risk. Information regarding invasive and noninvasive tests is collected during the time patients receive cardio-oncological care. Outcome data consist of the incidence of cardiovascular complications and major adverse cardiac events, and the impact of these events on the oncological treatment. Discussion: Outcomes of the ONCOR registry may aid in gaining more insight into the incidence of cancer therapy–related cardiovascular complications. The registry facilitates research on mechanisms of cardiovascular complications and on diagnostic, prognostic and therapeutic strategies. In addition, it provides a platform for future (interventional) studies. Centres with cardio-oncology services that are interested in contributing to the ONCOR registry are hereby invited to participate.

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U2 - 10.1007/s12471-020-01517-8

DO - 10.1007/s12471-020-01517-8

M3 - Article

AN - SCOPUS:85096090520

SN - 1568-5888

VL - 29

SP - 288

EP - 294

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 5

ER -

ONCOR: design of the Dutch cardio-oncology registry

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