TY - JOUR
T1 - One health, multiple challenges
T2 - The inter-species transmission of influenza A virus
AU - Short, Kirsty R.
AU - Richard, Mathilde
AU - Verhagen, Josanne H.
AU - van Riel, Debby
AU - Schrauwen, Eefje J.A.
AU - van den Brand, Judith M.A.
AU - Mänz, Benjamin
AU - Bodewes, Rogier
AU - Herfst, Sander
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/12
Y1 - 2015/12
N2 - Influenza A viruses are amongst the most challenging viruses that threaten both human and animal health. Influenza A viruses are unique in many ways. Firstly, they are unique in the diversity of host species that they infect. This includes waterfowl (the original reservoir), terrestrial and aquatic poultry, swine, humans, horses, dog, cats, whales, seals and several other mammalian species. Secondly, they are unique in their capacity to evolve and adapt, following crossing the species barrier, in order to replicate and spread to other individuals within the new species. Finally, they are unique in the frequency of inter-species transmission events that occur. Indeed, the consequences of novel influenza virus strain in an immunologically naïve population can be devastating. The problems that influenza A viruses present for human and animal health are numerous. For example, influenza A viruses in humans represent a major economic and disease burden, whilst the poultry industry has suffered colossal damage due to repeated outbreaks of highly pathogenic avian influenza viruses. This review aims to provide a comprehensive overview of influenza A viruses by shedding light on interspecies virus transmission and summarising the current knowledge regarding how influenza viruses can adapt to a new host.
AB - Influenza A viruses are amongst the most challenging viruses that threaten both human and animal health. Influenza A viruses are unique in many ways. Firstly, they are unique in the diversity of host species that they infect. This includes waterfowl (the original reservoir), terrestrial and aquatic poultry, swine, humans, horses, dog, cats, whales, seals and several other mammalian species. Secondly, they are unique in their capacity to evolve and adapt, following crossing the species barrier, in order to replicate and spread to other individuals within the new species. Finally, they are unique in the frequency of inter-species transmission events that occur. Indeed, the consequences of novel influenza virus strain in an immunologically naïve population can be devastating. The problems that influenza A viruses present for human and animal health are numerous. For example, influenza A viruses in humans represent a major economic and disease burden, whilst the poultry industry has suffered colossal damage due to repeated outbreaks of highly pathogenic avian influenza viruses. This review aims to provide a comprehensive overview of influenza A viruses by shedding light on interspecies virus transmission and summarising the current knowledge regarding how influenza viruses can adapt to a new host.
UR - http://www.scopus.com/inward/record.url?scp=84939779779&partnerID=8YFLogxK
U2 - 10.1016/j.onehlt.2015.03.001
DO - 10.1016/j.onehlt.2015.03.001
M3 - Article
C2 - 26309905
AN - SCOPUS:84939779779
SN - 2352-7714
VL - 1
SP - 1
EP - 13
JO - One Health
JF - One Health
ER -
