One health, multiple challenges: The inter-species transmission of influenza A virus

Kirsty R. Short, Mathilde Richard, Josanne H. Verhagen, Debby van Riel, Eefje J.A. Schrauwen, Judith M.A. van den Brand, Benjamin Mänz, Rogier Bodewes, Sander Herfst*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

104 Citations (Scopus)
3 Downloads (Pure)

Abstract

Influenza A viruses are amongst the most challenging viruses that threaten both human and animal health. Influenza A viruses are unique in many ways. Firstly, they are unique in the diversity of host species that they infect. This includes waterfowl (the original reservoir), terrestrial and aquatic poultry, swine, humans, horses, dog, cats, whales, seals and several other mammalian species. Secondly, they are unique in their capacity to evolve and adapt, following crossing the species barrier, in order to replicate and spread to other individuals within the new species. Finally, they are unique in the frequency of inter-species transmission events that occur. Indeed, the consequences of novel influenza virus strain in an immunologically naïve population can be devastating. The problems that influenza A viruses present for human and animal health are numerous. For example, influenza A viruses in humans represent a major economic and disease burden, whilst the poultry industry has suffered colossal damage due to repeated outbreaks of highly pathogenic avian influenza viruses. This review aims to provide a comprehensive overview of influenza A viruses by shedding light on interspecies virus transmission and summarising the current knowledge regarding how influenza viruses can adapt to a new host.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalOne Health
Volume1
DOIs
Publication statusPublished - Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 The Authors.

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