One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones

Wouter W. de Herder*, Günter Klöppel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
10 Downloads (Pure)

Abstract

One century ago, in 1922, Frederick G Banting, Charles H Best, James B Collip and John J R Macleod first published their experiments resulting in the isolation of a hypoglycemic factor, named insulin, from a solution extract from a dog’s pancreas. One year later, in 1923, a hyperglycemic factor named glucagon was isolated by Charles P Kimball and John R Murlin. In the following years, it could be demonstrated that pancreatic islet alpha- and beta-cell neoplasms and hyperplasias could inappropriately secrete excessive amounts of these two hormones. This review is a sequel to the discovery of insulin and glucagon and introduces the history of this fascinating group of neuroendocrine neoplasms and hyperplasias of the pancreas.

Original languageEnglish
Article numbere230046
Pages (from-to)RE
JournalEndocrine-Related Cancer
Volume30
Issue number9
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
This work did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Publisher Copyright:
© 2023 the author(s) Published by Bioscientifica Ltd.

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