Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024

Leandre Murhula Masirika; Jean Claude Udahemuka; Leonard Schuele; Pacifique Ndishimye; Saria Otani; Justin Bengehya Mbiribindi; Jean M. Marekani; Leandre Mutimbwa Mambo; Nadine Malyamungu Bubala; Marjan Boter; David F. Nieuwenhuijse; Trudie Lang; Ernest Balyahamwabo Kalalizi; Jean Pierre Musabyimana; Frank M. Aarestrup; Marion Koopmans; Bas B.Oude Munnink; Freddy Belesi Siangoli

doi:10.2807/1560-7917.ES.2024.29.11.2400106

Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024

Leandre Murhula Masirika^*
, Jean Claude Udahemuka
, Leonard Schuele
, Pacifique Ndishimye
, Saria Otani
, Justin Bengehya Mbiribindi
, Jean M. Marekani
, Leandre Mutimbwa Mambo
, Nadine Malyamungu Bubala
, Marjan Boter
, David F. Nieuwenhuijse
, Trudie Lang
, Ernest Balyahamwabo Kalalizi
, Jean Pierre Musabyimana
, Frank M. Aarestrup
, Marion Koopmans
, Bas B.Oude Munnink
, Freddy Belesi Siangoli

^*Corresponding author for this work

Virology

Centre de Recherche en Sciences Naturelles de Lwiro
University of Castilla-La Mancha
University of Rwanda
Stansile Research Organization
Dalhousie University
African Institute for Mathematical Sciences (Rwanda)
Technical University of Denmark
Division Provinciale de la Santé (South Kivu)
Université de Kinshasa
Zone de Santé de Kamituga
Hôpital Général de Référence de Kamituga
University of Oxford
Rwanda Biomedical Center

Research output: Contribution to journal › Article › Academic › peer-review

121 Citations (Scopus)

64 Downloads (Pure)

Abstract

Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.

Original language	English
Journal	Eurosurveillance
Volume	29
Issue number	11
DOIs	https://doi.org/10.2807/1560-7917.ES.2024.29.11.2400106
Publication status	Published - 14 Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.2807/1560-7917.ES.2024.29.11.2400106Licence: CC BY

eurosurv-29-11_1Final published version, 1.82 MBLicence: CC BY

Cite this

Masirika, L. M., Udahemuka, J. C., Schuele, L., Ndishimye, P., Otani, S., Mbiribindi, J. B., Marekani, J. M., Mambo, L. M., Bubala, N. M., Boter, M., Nieuwenhuijse, D. F., Lang, T., Kalalizi, E. B., Musabyimana, J. P., Aarestrup, F. M., Koopmans, M., Munnink, B. B. O., & Siangoli, F. B. (2024). Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024. Eurosurveillance, 29(11). https://doi.org/10.2807/1560-7917.ES.2024.29.11.2400106

@article{05f7346986124b69bf7eecf9ffb98db6,

title = "Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024",

abstract = "Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.",

author = "Masirika, \{Leandre Murhula\} and Udahemuka, \{Jean Claude\} and Leonard Schuele and Pacifique Ndishimye and Saria Otani and Mbiribindi, \{Justin Bengehya\} and Marekani, \{Jean M.\} and Mambo, \{Leandre Mutimbwa\} and Bubala, \{Nadine Malyamungu\} and Marjan Boter and Nieuwenhuijse, \{David F.\} and Trudie Lang and Kalalizi, \{Ernest Balyahamwabo\} and Musabyimana, \{Jean Pierre\} and Aarestrup, \{Frank M.\} and Marion Koopmans and Munnink, \{Bas B.Oude\} and Siangoli, \{Freddy Belesi\}",

year = "2024",

month = mar,

day = "14",

doi = "10.2807/1560-7917.ES.2024.29.11.2400106",

language = "English",

volume = "29",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "European Centre for Disease Prevention and Control (ECDC)",

number = "11",

}

Masirika, LM, Udahemuka, JC, Schuele, L, Ndishimye, P, Otani, S, Mbiribindi, JB, Marekani, JM, Mambo, LM, Bubala, NM, Boter, M , Nieuwenhuijse, DF, Lang, T, Kalalizi, EB, Musabyimana, JP, Aarestrup, FM, Koopmans, M , Munnink, BBO & Siangoli, FB 2024, 'Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024', Eurosurveillance, vol. 29, no. 11. https://doi.org/10.2807/1560-7917.ES.2024.29.11.2400106

TY - JOUR

T1 - Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024

AU - Masirika, Leandre Murhula

AU - Udahemuka, Jean Claude

AU - Schuele, Leonard

AU - Ndishimye, Pacifique

AU - Otani, Saria

AU - Mbiribindi, Justin Bengehya

AU - Marekani, Jean M.

AU - Mambo, Leandre Mutimbwa

AU - Bubala, Nadine Malyamungu

AU - Boter, Marjan

AU - Nieuwenhuijse, David F.

AU - Lang, Trudie

AU - Kalalizi, Ernest Balyahamwabo

AU - Musabyimana, Jean Pierre

AU - Aarestrup, Frank M.

AU - Koopmans, Marion

AU - Munnink, Bas B.Oude

AU - Siangoli, Freddy Belesi

PY - 2024/3/14

Y1 - 2024/3/14

N2 - Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.

AB - Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.

UR - https://www.scopus.com/pages/publications/85187969994

U2 - 10.2807/1560-7917.ES.2024.29.11.2400106

DO - 10.2807/1560-7917.ES.2024.29.11.2400106

M3 - Article

C2 - 38487886

AN - SCOPUS:85187969994

SN - 1025-496X

VL - 29

JO - Eurosurveillance

JF - Eurosurveillance

IS - 11

ER -

Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this