Ophthalmological findings in congenital cytomegalovirus infection: When to screen, when to treat?

Sofie Ghekiere; Karel Allegaert; Veerle Cossey; Marc Van Ranst; Catherine Cassiman; Ingele Casteels

doi:10.3928/01913913-20120710-03

Ophthalmological findings in congenital cytomegalovirus infection: When to screen, when to treat?

Sofie Ghekiere^*, Karel Allegaert, Veerle Cossey, Marc Van Ranst, Catherine Cassiman, Ingele Casteels

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

48 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is the leading cause of known congenital viral infections. Approximately 90% of congenitally infected newborns exhibit no clinical abnormalities at birth. In 5% to 15%, a wide spectrum of clinical signs is present at birth. Ophthalmological signs are seen in a large percentage of symptomatic patients but rarely in otherwise asymptomatic infants. Chorioretinitis, optic atrophy, and cortical visual impairment are the most frequent causes of visual problems in congenitally infected infants. There is no clear consensus in the literature on screening or treatment modalities concerning the ophthalmological aspects of congenital CMV. Further prospective studies are needed to set up guidelines for ophthalmological screening and treatment of infants with congenital CMV.

Original language	English
Pages (from-to)	274-282
Number of pages	9
Journal	Journal of Pediatric Ophthalmology and Strabismus
Volume	49
Issue number	5
DOIs	https://doi.org/10.3928/01913913-20120710-03
Publication status	Published - 10 Jul 2012
Externally published	Yes

Bibliographical note

Funding information:
The clinical research of Karel Allegaert is supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical investigatorship (1800209 N).

Copyright 2012

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title = "Ophthalmological findings in congenital cytomegalovirus infection: When to screen, when to treat?",

abstract = "Cytomegalovirus (CMV) is the leading cause of known congenital viral infections. Approximately 90\% of congenitally infected newborns exhibit no clinical abnormalities at birth. In 5\% to 15\%, a wide spectrum of clinical signs is present at birth. Ophthalmological signs are seen in a large percentage of symptomatic patients but rarely in otherwise asymptomatic infants. Chorioretinitis, optic atrophy, and cortical visual impairment are the most frequent causes of visual problems in congenitally infected infants. There is no clear consensus in the literature on screening or treatment modalities concerning the ophthalmological aspects of congenital CMV. Further prospective studies are needed to set up guidelines for ophthalmological screening and treatment of infants with congenital CMV.",

author = "Sofie Ghekiere and Karel Allegaert and Veerle Cossey and \{Van Ranst\}, Marc and Catherine Cassiman and Ingele Casteels",

note = "Funding information: The clinical research of Karel Allegaert is supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical investigatorship (1800209 N). Copyright 2012",

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doi = "10.3928/01913913-20120710-03",

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T2 - When to screen, when to treat?

AU - Ghekiere, Sofie

AU - Allegaert, Karel

AU - Cossey, Veerle

AU - Van Ranst, Marc

AU - Cassiman, Catherine

AU - Casteels, Ingele

N1 - Funding information: The clinical research of Karel Allegaert is supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical investigatorship (1800209 N). Copyright 2012

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N2 - Cytomegalovirus (CMV) is the leading cause of known congenital viral infections. Approximately 90% of congenitally infected newborns exhibit no clinical abnormalities at birth. In 5% to 15%, a wide spectrum of clinical signs is present at birth. Ophthalmological signs are seen in a large percentage of symptomatic patients but rarely in otherwise asymptomatic infants. Chorioretinitis, optic atrophy, and cortical visual impairment are the most frequent causes of visual problems in congenitally infected infants. There is no clear consensus in the literature on screening or treatment modalities concerning the ophthalmological aspects of congenital CMV. Further prospective studies are needed to set up guidelines for ophthalmological screening and treatment of infants with congenital CMV.

AB - Cytomegalovirus (CMV) is the leading cause of known congenital viral infections. Approximately 90% of congenitally infected newborns exhibit no clinical abnormalities at birth. In 5% to 15%, a wide spectrum of clinical signs is present at birth. Ophthalmological signs are seen in a large percentage of symptomatic patients but rarely in otherwise asymptomatic infants. Chorioretinitis, optic atrophy, and cortical visual impairment are the most frequent causes of visual problems in congenitally infected infants. There is no clear consensus in the literature on screening or treatment modalities concerning the ophthalmological aspects of congenital CMV. Further prospective studies are needed to set up guidelines for ophthalmological screening and treatment of infants with congenital CMV.

UR - https://www.scopus.com/pages/publications/84872590449

U2 - 10.3928/01913913-20120710-03

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JO - Journal of Pediatric Ophthalmology and Strabismus

JF - Journal of Pediatric Ophthalmology and Strabismus

IS - 5

ER -

Ophthalmological findings in congenital cytomegalovirus infection: When to screen, when to treat?

Abstract

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