Optimal temperature management in aortic arch surgery: A systematic review and network meta-analysis

Djamila Abjigitova*, Maximiliaan L. Notenboom, Kevin M. Veen, Gabriëlle van Tussenbroek, Jos A. Bekkers, Mostafa M. Mokhles, Ad J.J.C. Bogers

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

3 Citations (Scopus)
55 Downloads (Pure)


Objectives: New temperature management concepts of moderate and mild hypothermic circulatory arrest during aortic arch surgery have gained weight over profound cooling. Comparisons of all temperature levels have rarely been performed. We performed direct and indirect comparisons of deep hypothermic circulatory arrest (DHCA) (≤20°C), moderate hypothermic circulatory arrest (MHCA) (20.1–25°C), and mild hypothermic circulatory arrest (mild HCA) (≥25.1°C) in a network meta-analysis. Methods: The literature was systematically searched for all papers published through February 2022 reporting on clinical outcomes after aortic arch surgery utilizing DHCA, MHCA and mild HCA. The primary outcome was operative mortality. The secondary outcomes were postoperative stroke and acute kidney failure (AKI). Results: A total of 34 studies were included, with a total of 12,370 patients. DHCA was associated with significantly higher postoperative incidence of stroke when compared with MHCA (odds ratio [OR], 1.46, 95% confidence interval [CI], 1.19–1.78) and mild HCA: (OR, 1.50, 95% CI, 1.14–1.98). Furthermore, DHCA and MHCA were associated with higher operative mortality when compared with mild HCA (OR 1.71, 95% CI, 1.23–2.39 and OR 1.50, 95% CI, 1.12–2.00, respectively). Separate analysis of randomized and propensity score matched studies showed sustained increased risk of stroke with DHCA in contrast to MHCA and mild HCA (OR, 1.61, 95% CI, 1.18–2.20, p value =.0029 and OR, 1.74, 95% CI, 1.09–2.77, p value =.019). Conclusions: In the included studies, the moderate to mild hypothermia strategies were associated with decreased operative mortality and the risk of postoperative stroke. Large-scale prospective studies are warranted to further explore appropriate temperature management for the treatment of aortic arch pathologies.

Original languageEnglish
Pages (from-to)5379-5387
Number of pages9
JournalJournal of Cardiac Surgery
Issue number12
Early online date15 Nov 2022
Publication statusPublished - Dec 2022

Bibliographical note

Funding Information:
We thank dr. Wichor Bramer, biomedical information specialist from the Medical Library of Erasmus Medical Center for assisting in the searches.

Publisher Copyright:
© 2022 The Authors. Journal of Cardiac Surgery published by Wiley Periodicals LLC.


Dive into the research topics of 'Optimal temperature management in aortic arch surgery: A systematic review and network meta-analysis'. Together they form a unique fingerprint.

Cite this