Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients

Jason Voorneveld; Lana B.H. Keijzer; Mihai Strachinaru; Daniel J. Bowen; Ferit Onur Mutluer; Antonius F.W. Van Der Steen; Folkert J.Ten Cate; Nico De Jong; Hendrik J. Vos; Annemien E. Van Den Bosch; Johan G. Bosch

doi:10.1109/TUFFC.2021.3066082

Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients

Jason Voorneveld^*, Lana B.H. Keijzer, Mihai Strachinaru, Daniel J. Bowen, Ferit Onur Mutluer, Antonius F.W. Van Der Steen, Folkert J.Ten Cate, Nico De Jong, Hendrik J. Vos, Annemien E. Van Den Bosch, Johan G. Bosch

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

49 Downloads (Pure)

Abstract

High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion rates (0.3, 0.6, and 1.2 ml/min) and five acoustic output amplitudes (by varying transmit voltage: 5, 10, 15, 20, and 30 V - corresponding to mechanical indices of 0.01, 0.02, 0.03, 0.04, and 0.06 at 60-mm depth) were tested in 20 patients admitted for symptoms of heart failure. We assess the accuracy of HFR echoPIV against pulsed-wave Doppler acquisitions obtained for mitral inflow and aortic outflow. In terms of image quality, the 1.2-ml/min infusion rate provided the highest contrast-to-background ratio (CBR) (3-dB improvement over 0.3 ml/min). The highest acoustic output tested resulted in the lowest CBR. Increased acoustic output also resulted in increased microbubble disruption. For the echoPIV results, the 1.2-ml/min infusion rate provided the best vector quality and accuracy; mid-range acoustic outputs (corresponding to 15-20-V transmit voltages) provided the best agreement with the pulsed-wave Doppler. Overall, the highest infusion rate (1.2 ml/min) and mid-range acoustic output amplitudes provided the best image quality and echoPIV results.

Original language	English
Article number	9378576
Pages (from-to)	2432-2443
Number of pages	12
Journal	IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume	68
Issue number	7
Early online date	15 Mar 2021
DOIs	https://doi.org/10.1109/TUFFC.2021.3066082
Publication status	Published - Jul 2021

Bibliographical note

Funding Information:
Manuscript received November 27, 2020; accepted March 8, 2021. Date of publication March 15, 2021; date of current version June 29, 2021. This work was supported in part by ZonMw within the Innovative Medical Devices Initiative Program under the Project “Heart Failure and 4-D Flow”; and in part by the project “Ultrafast Ultrasound Imaging for Extended Diagnosis and Treatment of Vascular Disease (ULTRA-X-TREME)” with project number (P17-32) of the research programme “Perspectief” which is (partly) financed by the Dutch Research Council (NWO). (Corresponding author: Jason Voorneveld.) Jason Voorneveld and Johan G. Bosch are with the Department of Biomedical Engineering, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands (e-mail: j.voorneveld. . asmusmc.nl).

Publisher Copyright:
© 1986-2012 IEEE.

Access to Document

10.1109/TUFFC.2021.3066082Licence: CC BY

Optimization_of_Microbubble_Concentration_and_Acoustic_Pressure_for_Left_Ventricular_High-Frame-Rate_EchoPIV_in_PatientsFinal published version, 7.52 MBLicence: CC BY

Cite this

Voorneveld, J., Keijzer, L. B. H., Strachinaru, M., Bowen, D. J., Mutluer, F. O., Van Der Steen, A. F. W., Cate, F. J. T., De Jong, N., Vos, H. J., Van Den Bosch, A. E., & Bosch, J. G. (2021). Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(7), 2432-2443. Article 9378576. https://doi.org/10.1109/TUFFC.2021.3066082

@article{6cedea9abecc446b9b087c90e1771864,

title = "Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients",

abstract = "High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion rates (0.3, 0.6, and 1.2 ml/min) and five acoustic output amplitudes (by varying transmit voltage: 5, 10, 15, 20, and 30 V - corresponding to mechanical indices of 0.01, 0.02, 0.03, 0.04, and 0.06 at 60-mm depth) were tested in 20 patients admitted for symptoms of heart failure. We assess the accuracy of HFR echoPIV against pulsed-wave Doppler acquisitions obtained for mitral inflow and aortic outflow. In terms of image quality, the 1.2-ml/min infusion rate provided the highest contrast-to-background ratio (CBR) (3-dB improvement over 0.3 ml/min). The highest acoustic output tested resulted in the lowest CBR. Increased acoustic output also resulted in increased microbubble disruption. For the echoPIV results, the 1.2-ml/min infusion rate provided the best vector quality and accuracy; mid-range acoustic outputs (corresponding to 15-20-V transmit voltages) provided the best agreement with the pulsed-wave Doppler. Overall, the highest infusion rate (1.2 ml/min) and mid-range acoustic output amplitudes provided the best image quality and echoPIV results. ",

author = "Jason Voorneveld and Keijzer, {Lana B.H.} and Mihai Strachinaru and Bowen, {Daniel J.} and Mutluer, {Ferit Onur} and {Van Der Steen}, {Antonius F.W.} and Cate, {Folkert J.Ten} and {De Jong}, Nico and Vos, {Hendrik J.} and {Van Den Bosch}, {Annemien E.} and Bosch, {Johan G.}",

note = "Funding Information: Manuscript received November 27, 2020; accepted March 8, 2021. Date of publication March 15, 2021; date of current version June 29, 2021. This work was supported in part by ZonMw within the Innovative Medical Devices Initiative Program under the Project “Heart Failure and 4-D Flow”; and in part by the project “Ultrafast Ultrasound Imaging for Extended Diagnosis and Treatment of Vascular Disease (ULTRA-X-TREME)” with project number (P17-32) of the research programme “Perspectief” which is (partly) financed by the Dutch Research Council (NWO). (Corresponding author: Jason Voorneveld.) Jason Voorneveld and Johan G. Bosch are with the Department of Biomedical Engineering, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands (e-mail: j.voorneveld. . asmusmc.nl). Publisher Copyright: {\textcopyright} 1986-2012 IEEE.",

year = "2021",

month = jul,

doi = "10.1109/TUFFC.2021.3066082",

language = "English",

volume = "68",

pages = "2432--2443",

journal = "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control",

issn = "0885-3010",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "7",

}

Voorneveld, J, Keijzer, LBH, Strachinaru, M , Bowen, DJ , Mutluer, FO , Van Der Steen, AFW , Cate, FJT, De Jong, N, Vos, HJ , Van Den Bosch, AE & Bosch, JG 2021, 'Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 68, no. 7, 9378576, pp. 2432-2443. https://doi.org/10.1109/TUFFC.2021.3066082

Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients. / Voorneveld, Jason; Keijzer, Lana B.H.; Strachinaru, Mihai et al.
In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 68, No. 7, 9378576, 07.2021, p. 2432-2443.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients

AU - Voorneveld, Jason

AU - Keijzer, Lana B.H.

AU - Strachinaru, Mihai

AU - Bowen, Daniel J.

AU - Mutluer, Ferit Onur

AU - Van Der Steen, Antonius F.W.

AU - Cate, Folkert J.Ten

AU - De Jong, Nico

AU - Vos, Hendrik J.

AU - Van Den Bosch, Annemien E.

AU - Bosch, Johan G.

N1 - Funding Information: Manuscript received November 27, 2020; accepted March 8, 2021. Date of publication March 15, 2021; date of current version June 29, 2021. This work was supported in part by ZonMw within the Innovative Medical Devices Initiative Program under the Project “Heart Failure and 4-D Flow”; and in part by the project “Ultrafast Ultrasound Imaging for Extended Diagnosis and Treatment of Vascular Disease (ULTRA-X-TREME)” with project number (P17-32) of the research programme “Perspectief” which is (partly) financed by the Dutch Research Council (NWO). (Corresponding author: Jason Voorneveld.) Jason Voorneveld and Johan G. Bosch are with the Department of Biomedical Engineering, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands (e-mail: j.voorneveld. . asmusmc.nl). Publisher Copyright: © 1986-2012 IEEE.

PY - 2021/7

Y1 - 2021/7

N2 - High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion rates (0.3, 0.6, and 1.2 ml/min) and five acoustic output amplitudes (by varying transmit voltage: 5, 10, 15, 20, and 30 V - corresponding to mechanical indices of 0.01, 0.02, 0.03, 0.04, and 0.06 at 60-mm depth) were tested in 20 patients admitted for symptoms of heart failure. We assess the accuracy of HFR echoPIV against pulsed-wave Doppler acquisitions obtained for mitral inflow and aortic outflow. In terms of image quality, the 1.2-ml/min infusion rate provided the highest contrast-to-background ratio (CBR) (3-dB improvement over 0.3 ml/min). The highest acoustic output tested resulted in the lowest CBR. Increased acoustic output also resulted in increased microbubble disruption. For the echoPIV results, the 1.2-ml/min infusion rate provided the best vector quality and accuracy; mid-range acoustic outputs (corresponding to 15-20-V transmit voltages) provided the best agreement with the pulsed-wave Doppler. Overall, the highest infusion rate (1.2 ml/min) and mid-range acoustic output amplitudes provided the best image quality and echoPIV results.

AB - High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion rates (0.3, 0.6, and 1.2 ml/min) and five acoustic output amplitudes (by varying transmit voltage: 5, 10, 15, 20, and 30 V - corresponding to mechanical indices of 0.01, 0.02, 0.03, 0.04, and 0.06 at 60-mm depth) were tested in 20 patients admitted for symptoms of heart failure. We assess the accuracy of HFR echoPIV against pulsed-wave Doppler acquisitions obtained for mitral inflow and aortic outflow. In terms of image quality, the 1.2-ml/min infusion rate provided the highest contrast-to-background ratio (CBR) (3-dB improvement over 0.3 ml/min). The highest acoustic output tested resulted in the lowest CBR. Increased acoustic output also resulted in increased microbubble disruption. For the echoPIV results, the 1.2-ml/min infusion rate provided the best vector quality and accuracy; mid-range acoustic outputs (corresponding to 15-20-V transmit voltages) provided the best agreement with the pulsed-wave Doppler. Overall, the highest infusion rate (1.2 ml/min) and mid-range acoustic output amplitudes provided the best image quality and echoPIV results.

UR - http://www.scopus.com/inward/record.url?scp=85103168819&partnerID=8YFLogxK

U2 - 10.1109/TUFFC.2021.3066082

DO - 10.1109/TUFFC.2021.3066082

M3 - Article

C2 - 33720832

AN - SCOPUS:85103168819

SN - 0885-3010

VL - 68

SP - 2432

EP - 2443

JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

IS - 7

M1 - 9378576

ER -

Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this