Optimizing the outcome of surgery in patients with rectal cancer and synchronous liver metastases

Anne Pool, JHW (Johannes) de Wilt, Zarina Lalmahomed, Lex Eggermont, J.N.M. IJzermans, Kees Verhoef

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83 Citations (Scopus)


Background: This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy. Methods: All patients undergoing surgical treatment of rectal cancer and synchronous liver metastases between 2000 and 2007 were identified retrospectively from a Prospectively collected database. Three approaches were followed: the classical staged, the simultaneous and the liver-first approach. Results: Of 57 patients identified, the primary turnout was resected first in 29 patients (group 1), simultaneous resection was performed in eight patients (group 2), and 20 patients underwent a liver-first approach (group 3). The overall morbidity rate was 24.6 per cent; there was no in-hospital mortality. Median in-hospital stay was significantly shorter for the simultaneous approach (9 days versus 18 and 15 days for groups I and 3 respectively; P < 0.001). The overall 5-year survival rate was 38 per cent, with an estimated median survival of 47 months. Conclusion: Long-term survival can be achieved using an individualized approach, with curative intent, in patients with rectal cancer and synchronous liver metastases. Simultaneous resections as well as the liver-first approach are attractive alternatives to traditional staged resections.
Original languageUndefined/Unknown
Pages (from-to)383-390
Number of pages8
JournalBritish Journal of Surgery
Issue number3
Publication statusPublished - 2010

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