Oral Glucose Tolerance Test for the Screening of Glucose Intolerance Long Term Post‐Heart Transplantation

Stefan Roest, Marleen M. Goedendorp-Sluimer, Julia J. Köbben, Alina A. Constantinescu, Yannick J.H.J. Taverne, Felix Zijlstra, Adrienne A.M. Zandbergen, Olivier C. Manintveld*

*Corresponding author for this work

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Abstract

Post-transplant diabetes mellitus (PTDM) is a frequent complication post-heart transplantation (HT), however long-term prevalence studies are missing. The aim of this study was to determine the prevalence and determinants of PTDM as well as prediabetes long-term post-HT using oral glucose tolerance tests (OGTT). Also, the additional value of OGTT compared to fasting glucose and glycated hemoglobin (HbA1c) was investigated. All patients > 1 year post-HT seen at the outpatient clinic between August 2018 and April 2021 were screened with an OGTT. Patients with known diabetes, an active infection/rejection/malignancy or patients unwilling or unable to undergo OGTT were excluded. In total, 263 patients were screened, 108 were excluded. The included 155 patients had a median age of 54.3 [42.2–64.3] years, and 63 (41%) were female. Median time since HT was 8.5 [4.8–14.5] years. Overall, 51 (33%) had a normal range, 85 (55%) had a prediabetes range and 19 (12%) had a PTDM range test. OGTT identified prediabetes and PTDM in more patients (18% and 50%, respectively), than fasting glucose levels and HbA1c. Age at HT (OR 1.03 (1.00–1.06), p = 0.044) was a significant determinant of an abnormal OGTT. Prediabetes as well as PTDM are frequently seen long-term post-HT. OGTT is the preferred screening method.

Original languageEnglish
Article number10113
JournalTransplant International
Volume35
DOIs
Publication statusPublished - 19 Apr 2022

Bibliographical note

Publisher Copyright: Copyright © 2022 Roest, Goedendorp-Sluimer, Köbben, Constantinescu, Taverne, Zijlstra, Zandbergen and Manintveld.

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