Origin and functional specializations of DC subsets in the lung

M Plantinga, H (Hamida) Hammad, Bart Lambrecht

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Abstract

Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.
Original languageUndefined/Unknown
Pages (from-to)2112-2118
Number of pages7
JournalEuropean Journal of Immunology
Volume40
Issue number8
DOIs
Publication statusPublished - 2010

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