Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012

A (Adam) Meijer; Marcel Jonges; P van Beek; CM Swaan; Ab Osterhaus; RS Daniels; AC Hurt; Marion Koopmans

Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012

A (Adam) Meijer, Marcel Jonges, P van Beek, CM Swaan, Ab Osterhaus, RS Daniels, AC Hurt, Marion Koopmans

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Abstract

Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.

Original language	Undefined/Unknown
Pages (from-to)	2-8
Number of pages	7
Journal	Eurosurveillance
Volume	17
Issue number	36
Publication status	Published - 2012

Research programs

EMC MM-04-27-01

Cite this

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title = "Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012",

abstract = "Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.",

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T1 - Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012

AU - Meijer, A (Adam)

AU - Jonges, Marcel

AU - van Beek, P

AU - Swaan, CM

AU - Osterhaus, Ab

AU - Daniels, RS

AU - Hurt, AC

AU - Koopmans, Marion

PY - 2012

Y1 - 2012

N2 - Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.

AB - Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.

M3 - Article

SN - 1560-7917

VL - 17

SP - 2

EP - 8

JO - Eurosurveillance

JF - Eurosurveillance

IS - 36

ER -