Osteoprotegerin Is Associated With Aneurysm Diameter and Proteolysis in Abdominal Aortic Aneurysm Disease

D Koole, R Hurks, A Schoneveld, A (Ard) Vink, J Golledge, CS Moran, DP de Kleijn, JA van Herwaarden, JP de Vries, Jon Laman, Ruth Huizinga, G Pasterkamp, FL Moll

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Abstract

Objective-Serum osteoprotegerin (OPG) concentrations have previously been associated with growth of abdominal aortic aneurysms (AAAs). In vitro experiments showed that OPG promotes matrix metalloprotease (MMP) release from monocytes and vascular smooth muscle cells. We hypothesized that OPG expression is increased in human AAAs and is associated with proteolysis. Methods and Results-AAA biopsies were collected from 329 patients. We assessed the concentrations of OPG, cathepsins A, B, and S as well as the activity of MMP-2 and MMP-9. The AAA wall infiltration by macrophages, lymphocytes, and plasma cells was estimated by immunohistochemistry. The concentration of OPG correlated positively with aortic diameter (<55 mm: 16.1 [5.8-28.7], 55-70 mm: 21.9 [10.2-36.0], >70 mm: 24.0 [13.5-52.9] ng OPG/mg total amount of protein, P=0.020), cathepsin A (r=0.221, P= Conclusion-The concentration of aortic wall OPG is positively associated with established markers of AAA severity and pathogenesis. OPG appeared to be associated with lymphocytes and plasma cells. These human data support previous experimental data suggesting a role for OPG in AAA pathogenesis. (Arterioscler Thromb Vasc Biol. 2012;32:1497-1504.)
Original languageUndefined/Unknown
Pages (from-to)1497-+
JournalArteriosclerosis Thrombosis & Vascular Biology
Volume32
Issue number6
DOIs
Publication statusPublished - 2012

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