Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands

Peggy Vencken, W Reitsma, Mieke Kriege, MJE Mourits, GH de Bock, JA de Hullu, AM van Altena, KN Gaarenstroom, HFA Vasen, MA (Muriel) Adank, Marjanka K Schmidt, M van Beurden, RP Zweemer, F Rijcken, BFM Slangen, Curt Burger, Caroline Seynaeve

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Recent studies suggested an improved overall survival (OS) for BRCA2- versus BRCA1-associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients. Two hundred and forty-five BRCA1- and 99 BRCA2-associated EOC patients were identified through all Dutch university hospitals. Analyses were carried out with the Pearson's Chi-square test, Kaplan-Meier, and Cox regression methods. BRCA1 patients were younger at EOC diagnosis than BRCA2 patients (51 versus 55 years; P < 0.001), without differences regarding histology, tumor grade, and International Federation of Gynecology and Obstetrics (FIGO) stage. Complete response rates after primary treatment, including chemotherapy, did not differ between BRCA1 (86%) and BRCA2 patients (90%). BRCA1 versus BRCA2 patients had a shorter PFS (median 2.2 versus 3.9 years, respectively; P = 0.006), TFI (median 1.7 versus 2.8 years; P = 0. PFS and OS were substantially longer in BRCA2- than in BRCA1-associated EOC patients. While response rates after primary treatment were similarly high in both groups, TFI, as surrogate for chemosensitivity, was significantly longer in BRCA2 patients.
Original languageEnglish
Pages (from-to)2036-2042
Number of pages7
JournalAnnals of Oncology
Volume24
Issue number8
DOIs
Publication statusPublished - 2013

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