Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa

Xuan Thanh An Nguyen, Alberta A.H.J. Thiadens, Marta Fiocco, Weijen Tan, Martin McKibbin, Caroline C.W. Klaver, Magda A. Meester-Smoor, Caroline Van Cauwenbergh, Ine Strubbe, Andrea Vergaro, Jan Willem R. Pott, Carel B. Hoyng, Bart P. Leroy, Reda Zemaitiene, Kamron N. Khan, Camiel J.F. Boon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
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PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAmerican Journal of Ophthalmology
Publication statusPublished - 1 Feb 2023

Bibliographical note

Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234)from The Ministry
of Education, Youth and Sports, Czech Republic (to A.V.).

Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE).
ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded
by the Hôpitaux Universitaires de Strasbourg.

Publisher Copyright: © 2022 The Author(s)


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