Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa

Xuan Thanh An Nguyen; Alberta A.H.J. Thiadens; Marta Fiocco; Weijen Tan; Martin McKibbin; Caroline C.W. Klaver; Magda A. Meester-Smoor; Caroline Van Cauwenbergh; Ine Strubbe; Andrea Vergaro; Jan Willem R. Pott; Carel B. Hoyng; Bart P. Leroy; Reda Zemaitiene; Kamron N. Khan; Camiel J.F. Boon

doi:10.1016/j.ajo.2022.10.001

Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa

Xuan Thanh An Nguyen, Alberta A.H.J. Thiadens, Marta Fiocco, Weijen Tan, Martin McKibbin, Caroline C.W. Klaver, Magda A. Meester-Smoor, Caroline Van Cauwenbergh, Ine Strubbe, Andrea Vergaro, Jan Willem R. Pott, Carel B. Hoyng, Bart P. Leroy, Reda Zemaitiene, Kamron N. Khan, Camiel J.F. Boon^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	American Journal of Ophthalmology
Volume	246
DOIs	https://doi.org/10.1016/j.ajo.2022.10.001
Publication status	Published - 1 Feb 2023

Bibliographical note

Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234)from The Ministry
of Education, Youth and Sports, Czech Republic (to A.V.).

Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE).
ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded
by the Hôpitaux Universitaires de Strasbourg.

Publisher Copyright: © 2022 The Author(s)

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PIIS0002939422003890Final published version, 597 KBLicence: CC BY

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Nguyen, X. T. A., Thiadens, A. A. H. J., Fiocco, M., Tan, W., McKibbin, M., Klaver, C. C. W., Meester-Smoor, M. A., Van Cauwenbergh, C., Strubbe, I., Vergaro, A., Pott, J. W. R., Hoyng, C. B., Leroy, B. P., Zemaitiene, R., Khan, K. N., & Boon, C. J. F. (2023). Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa. American Journal of Ophthalmology, 246, 1-9. https://doi.org/10.1016/j.ajo.2022.10.001

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title = "Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa",

abstract = "PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.",

author = "Nguyen, {Xuan Thanh An} and Thiadens, {Alberta A.H.J.} and Marta Fiocco and Weijen Tan and Martin McKibbin and Klaver, {Caroline C.W.} and Meester-Smoor, {Magda A.} and {Van Cauwenbergh}, Caroline and Ine Strubbe and Andrea Vergaro and Pott, {Jan Willem R.} and Hoyng, {Carel B.} and Leroy, {Bart P.} and Reda Zemaitiene and Khan, {Kamron N.} and Boon, {Camiel J.F.}",

note = "Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234)from The Ministry of Education, Youth and Sports, Czech Republic (to A.V.). Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE). ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded by the H{\^o}pitaux Universitaires de Strasbourg. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

month = feb,

day = "1",

doi = "10.1016/j.ajo.2022.10.001",

language = "English",

volume = "246",

pages = "1--9",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

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Nguyen, XTA, Thiadens, AAHJ, Fiocco, M, Tan, W, McKibbin, M, Klaver, CCW , Meester-Smoor, MA, Van Cauwenbergh, C, Strubbe, I, Vergaro, A, Pott, JWR, Hoyng, CB, Leroy, BP, Zemaitiene, R, Khan, KN & Boon, CJF 2023, 'Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa', American Journal of Ophthalmology, vol. 246, pp. 1-9. https://doi.org/10.1016/j.ajo.2022.10.001

TY - JOUR

T1 - Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa

AU - Nguyen, Xuan Thanh An

AU - Thiadens, Alberta A.H.J.

AU - Fiocco, Marta

AU - Tan, Weijen

AU - McKibbin, Martin

AU - Klaver, Caroline C.W.

AU - Meester-Smoor, Magda A.

AU - Van Cauwenbergh, Caroline

AU - Strubbe, Ine

AU - Vergaro, Andrea

AU - Pott, Jan Willem R.

AU - Hoyng, Carel B.

AU - Leroy, Bart P.

AU - Zemaitiene, Reda

AU - Khan, Kamron N.

AU - Boon, Camiel J.F.

N1 - Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234)from The Ministry of Education, Youth and Sports, Czech Republic (to A.V.). Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE). ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded by the Hôpitaux Universitaires de Strasbourg. Publisher Copyright: © 2022 The Author(s)

PY - 2023/2/1

Y1 - 2023/2/1

N2 - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.

AB - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.

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U2 - 10.1016/j.ajo.2022.10.001

DO - 10.1016/j.ajo.2022.10.001

M3 - Article

C2 - 36252678

AN - SCOPUS:85142309973

SN - 0002-9394

VL - 246

SP - 1

EP - 9

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

ER -

Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa

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