Outcome of radiotherapy in T1 glottic carcinoma: a population-based study

EV Sjogren, RGJ Wiggenraad, S le Cessie, S Snijder, J Pomp, R.J. Baatenburg de Jong

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
1 Downloads (Pure)

Abstract

We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.
Original languageUndefined/Unknown
Pages (from-to)735-744
Number of pages10
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume266
Issue number5
DOIs
Publication statusPublished - 2009

Cite this