Outcome of radiotherapy in T1 glottic carcinoma: a population-based study

EV Sjogren; RGJ Wiggenraad; S le Cessie; S Snijder; J Pomp; R.J. Baatenburg de Jong

doi:10.1007/s00405-008-0803-9

Outcome of radiotherapy in T1 glottic carcinoma: a population-based study

EV Sjogren, RGJ Wiggenraad, S le Cessie, S Snijder, J Pomp, R.J. Baatenburg de Jong

Otorhinolaryngology and Head and Neck Surgery

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.

Original language	Undefined/Unknown
Pages (from-to)	735-744
Number of pages	10
Journal	European Archives of Oto-Rhino-Laryngology
Volume	266
Issue number	5
DOIs	https://doi.org/10.1007/s00405-008-0803-9
Publication status	Published - 2009

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http://hdl.handle.net/1765/24179

Cite this

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title = "Outcome of radiotherapy in T1 glottic carcinoma: a population-based study",

abstract = "We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.",

author = "EV Sjogren and RGJ Wiggenraad and {le Cessie}, S and S Snijder and J Pomp and {Baatenburg de Jong}, R.J.",

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AU - Sjogren, EV

AU - Wiggenraad, RGJ

AU - le Cessie, S

AU - Snijder, S

AU - Pomp, J

AU - Baatenburg de Jong, R.J.

PY - 2009

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AB - We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West region of the western Netherlands. Median follow-up was 70 months (range 1-190 months). Five and ten-year local control was 86 and 84%. Disease specific survival was 97% at 5 and 10 years. In multivariate analysis, pre-existent laryngeal hypertrophic laryngitis was the only predictive factor for local control (relative risk = 3.0, P = 0.02). Comorbidity was prognostic for overall survival. No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy.

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