PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy

G Papatheodoridis, G Dalekos, V Sypsa, C Yurdaydin, M Buti, J Goulis, JL Calleja, Heng Chi, S Manolakopoulos, G Mangia, N Gatselis, O Keskin, S Savvidou, J de la Revilla, Bettina Hansen, I Vlachogiannakos, K Galanis, R Idilman, M Colombo, R EstebanHLA Janssen, P Lampertico

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Abstract

Background & Aims: Risk scores for hepatocellular carcinoma (HCC) developed in Asians offer poor-moderate predictability in Caucasian patients with chronic hepatitis B (CHB). This nine center cohort study aimed to develop and validate an accurate HCC risk score in Caucasian CHB patients treated with the current oral antivirals, entecavir/tenofovir. Methods: We included 1815 adult Caucasians with CHB and no HCC at baseline who received entecavir/tenofovir for >= 12 months. Using data from eight centers (derivation dataset, n = 1325), a HCC risk score was developed based on multivariable Cox models and points system for simplification. Harrell's c-index was used as discrimination, bootstrap for internal validation and the data from the 9th and largest center (validation dataset, n = 490) for external validation. Results: The 5-year cumulative HCC incidence rates were 5.7% and 8.4% in the derivation and validation dataset, respectively. In the derivation dataset, age, gender, platelets and cirrhosis were independently associated with HCC. The PAGE-B score was developed based on age, gender and platelets (c-index = 0.82, 0.81 after bootstrap validation). The addition of cirrhosis did not substantially improve the discrimination (c-index = 0.84). The predictability of PAGE-B score was similar (c-index = 0.82) in the validation dataset. Patients with PAGE-B 10-17, >= 18 had 5-year cumulative HCC incidence rates of 0%, 3%, 17% in the derivation and 0%, 4%, 16% in the validation dataset. Conclusion: PAGE-B, which is based only on baseline patients' age, gender and platelets, represents a simple and reliable score for prediction of the 5-year HCC risk in Caucasian CHB patients under entecavir/tenofovir. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)800-806
Number of pages7
JournalJournal of Hepatology
Volume64
Issue number4
DOIs
Publication statusPublished - 2016

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