Pain perception in women with menstrually-related migraine

Katie M. Linstra; Khatera Ibrahimi; Daphne S. van Casteren; Marieke J.H. Wermer; Gisela M. Terwindt; Antoinette MaassenVanDenBrink

doi:10.1177/0333102420966977

Pain perception in women with menstrually-related migraine

Katie M. Linstra
, Khatera Ibrahimi
, Daphne S. van Casteren
, Marieke J.H. Wermer
, Gisela M. Terwindt
, Antoinette MaassenVanDenBrink^*

^*Corresponding author for this work

Internal Medicine

Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

78 Downloads (Pure)

Abstract

Background: Cyclic hormonal fluctuations influence migraine incidence and severity. Previously, we described reduced menstrual cyclicity in estradiol levels and dermal blood flow reaction to capsaicin in female migraineurs. It is unclear whether pain perception in women with migraine is influenced by the menstrual cycle. Methods: Women with menstrually-related migraine (n = 14), healthy age-matched controls (n = 10) and postmenopausal women (n = 15) were asked to grade trigeminal and non-trigeminal painful stimuli on a numeric pain rating scale on menstrual cycle day 19–21 (mid-luteal) and day 1–2 (early follicular). Results: In women with menstrually-related migraine, trigeminal pain remained low throughout the cycle. Controls showed increased trigeminal pain during the mid-luteal phase compared to the early follicular phase. Changes throughout the cycle were significantly different between women with MRM and controls. Conclusion: The compromised menstrual cyclicity of pain perception in women with menstrually-related migraine parallels our earlier findings on estradiol levels and dermal blood flow.

Original language	English
Pages (from-to)	417-421
Number of pages	5
Journal	Cephalalgia
Volume	41
Issue number	3
Early online date	21 Oct 2020
DOIs	https://doi.org/10.1177/0333102420966977
Publication status	Published - Mar 2021

Bibliographical note

Funding Information:
MJHW was supported by a ZonMw/NWO VIDI (grant number 9171733); GMT was supported by a ZonMw/NWO VIDI (grant number 91711319), reports grants or consultancy support from Novartis, Lilly, Teva, and independent support from NWO, ZonMw, NIH, European Community, Dutch Heart Foundation, and Dutch Brain Foundation.

Funding Information:
The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: KML was supported by grant of the Dutch Heart Foundation (grant number 2013T083); KI received support for conference visits from Menarini and MSD; DSVC reports no disclosures.

Funding Information:
AMVDB was supported by a ZonMw/NWO VIDI (grant number 917113349), has received fees and grant support from the following organizations over the most recent 5 year period: Amgen/Novartis, Lilly/CoLucid, Teva and ATI.

Publisher Copyright:
© International Headache Society 2020.

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Pain perception in women with menstrually-related migraineFinal published version, 311 KBLicence: CC BY

Cite this

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title = "Pain perception in women with menstrually-related migraine",

abstract = "Background: Cyclic hormonal fluctuations influence migraine incidence and severity. Previously, we described reduced menstrual cyclicity in estradiol levels and dermal blood flow reaction to capsaicin in female migraineurs. It is unclear whether pain perception in women with migraine is influenced by the menstrual cycle. Methods: Women with menstrually-related migraine (n = 14), healthy age-matched controls (n = 10) and postmenopausal women (n = 15) were asked to grade trigeminal and non-trigeminal painful stimuli on a numeric pain rating scale on menstrual cycle day 19–21 (mid-luteal) and day 1–2 (early follicular). Results: In women with menstrually-related migraine, trigeminal pain remained low throughout the cycle. Controls showed increased trigeminal pain during the mid-luteal phase compared to the early follicular phase. Changes throughout the cycle were significantly different between women with MRM and controls. Conclusion: The compromised menstrual cyclicity of pain perception in women with menstrually-related migraine parallels our earlier findings on estradiol levels and dermal blood flow.",

author = "Linstra, \{Katie M.\} and Khatera Ibrahimi and \{van Casteren\}, \{Daphne S.\} and Wermer, \{Marieke J.H.\} and Terwindt, \{Gisela M.\} and Antoinette MaassenVanDenBrink",

note = "Funding Information: MJHW was supported by a ZonMw/NWO VIDI (grant number 9171733); GMT was supported by a ZonMw/NWO VIDI (grant number 91711319), reports grants or consultancy support from Novartis, Lilly, Teva, and independent support from NWO, ZonMw, NIH, European Community, Dutch Heart Foundation, and Dutch Brain Foundation. Funding Information: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: KML was supported by grant of the Dutch Heart Foundation (grant number 2013T083); KI received support for conference visits from Menarini and MSD; DSVC reports no disclosures. Funding Information: AMVDB was supported by a ZonMw/NWO VIDI (grant number 917113349), has received fees and grant support from the following organizations over the most recent 5 year period: Amgen/Novartis, Lilly/CoLucid, Teva and ATI. Publisher Copyright: {\textcopyright} International Headache Society 2020.",

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doi = "10.1177/0333102420966977",

language = "English",

volume = "41",

pages = "417--421",

journal = "Cephalalgia",

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number = "3",

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AU - Linstra, Katie M.

AU - Ibrahimi, Khatera

AU - van Casteren, Daphne S.

AU - Wermer, Marieke J.H.

AU - Terwindt, Gisela M.

AU - MaassenVanDenBrink, Antoinette

N1 - Funding Information: MJHW was supported by a ZonMw/NWO VIDI (grant number 9171733); GMT was supported by a ZonMw/NWO VIDI (grant number 91711319), reports grants or consultancy support from Novartis, Lilly, Teva, and independent support from NWO, ZonMw, NIH, European Community, Dutch Heart Foundation, and Dutch Brain Foundation. Funding Information: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: KML was supported by grant of the Dutch Heart Foundation (grant number 2013T083); KI received support for conference visits from Menarini and MSD; DSVC reports no disclosures. Funding Information: AMVDB was supported by a ZonMw/NWO VIDI (grant number 917113349), has received fees and grant support from the following organizations over the most recent 5 year period: Amgen/Novartis, Lilly/CoLucid, Teva and ATI. Publisher Copyright: © International Headache Society 2020.

PY - 2021/3

Y1 - 2021/3

N2 - Background: Cyclic hormonal fluctuations influence migraine incidence and severity. Previously, we described reduced menstrual cyclicity in estradiol levels and dermal blood flow reaction to capsaicin in female migraineurs. It is unclear whether pain perception in women with migraine is influenced by the menstrual cycle. Methods: Women with menstrually-related migraine (n = 14), healthy age-matched controls (n = 10) and postmenopausal women (n = 15) were asked to grade trigeminal and non-trigeminal painful stimuli on a numeric pain rating scale on menstrual cycle day 19–21 (mid-luteal) and day 1–2 (early follicular). Results: In women with menstrually-related migraine, trigeminal pain remained low throughout the cycle. Controls showed increased trigeminal pain during the mid-luteal phase compared to the early follicular phase. Changes throughout the cycle were significantly different between women with MRM and controls. Conclusion: The compromised menstrual cyclicity of pain perception in women with menstrually-related migraine parallels our earlier findings on estradiol levels and dermal blood flow.

AB - Background: Cyclic hormonal fluctuations influence migraine incidence and severity. Previously, we described reduced menstrual cyclicity in estradiol levels and dermal blood flow reaction to capsaicin in female migraineurs. It is unclear whether pain perception in women with migraine is influenced by the menstrual cycle. Methods: Women with menstrually-related migraine (n = 14), healthy age-matched controls (n = 10) and postmenopausal women (n = 15) were asked to grade trigeminal and non-trigeminal painful stimuli on a numeric pain rating scale on menstrual cycle day 19–21 (mid-luteal) and day 1–2 (early follicular). Results: In women with menstrually-related migraine, trigeminal pain remained low throughout the cycle. Controls showed increased trigeminal pain during the mid-luteal phase compared to the early follicular phase. Changes throughout the cycle were significantly different between women with MRM and controls. Conclusion: The compromised menstrual cyclicity of pain perception in women with menstrually-related migraine parallels our earlier findings on estradiol levels and dermal blood flow.

UR - https://www.scopus.com/pages/publications/85093825519

U2 - 10.1177/0333102420966977

DO - 10.1177/0333102420966977

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AN - SCOPUS:85093825519

SN - 0333-1024

VL - 41

SP - 417

EP - 421

JO - Cephalalgia

JF - Cephalalgia

IS - 3

ER -

Pain perception in women with menstrually-related migraine

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