Painful and swollen tongue: mucosal leishmaniasis due to Leishmania infantum

Ga Lai M. Chong; David SY Ong; Mariana de Mendonça Melo; Jaap J. van Hellemond

doi:10.1016/j.ijid.2021.09.071

Painful and swollen tongue: mucosal leishmaniasis due to Leishmania infantum

Ga Lai M. Chong^*
, David SY Ong
, Mariana de Mendonça Melo
, Jaap J. van Hellemond

^*Corresponding author for this work

Franciscus Gasthuis & Vlietland
Department of Medical Microbiology and Infection Control
University Medical Centre Utrecht

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background:: Leishmaniasis is a parasitic disease caused by different Leishmania species. L. infantum is found in the Mediterranean area. It usually causes visceral or cutaneous leishmaniasis, but rarely mucosal leishmaniasis (ML). Methods:: A 62-year-old man with metastatic non-small-cell lung carcinoma visited the outpatient clinic because of a painful and swollen tongue. Initially, oral candidiasis was suspected and patient was unsuccessfully treated accordingly. Subsequently, a biopsy from the tongue was taken. Results:: Histology of the tongue biopsy showed an inflammation with histiocytes and Leishmania amastigotes. Molecular analysis determined these parasites as L. donovani complex. Based on the patient's travel history, ML caused by L. infantum was diagnosed. Conclusion:: ML is an unusual presentation of L. infantum. ML is not only caused by Leishmania species endemic in Latin America, but also should be considered in the differential diagnosis for European patients. A biopsy of the affected location is needed to confirm the diagnosis.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	International Journal of Infectious Diseases
Volume	113
Early online date	28 Sept 2021
DOIs	https://doi.org/10.1016/j.ijid.2021.09.071
Publication status	Published - 1 Dec 2021

Bibliographical note

Funding Information:
We would like to thank Suzanna Broerse (Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands) for supplying specific clinical information and Klaas Hoogduin (Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands) for analysing and describing the histologic specimen. Titia Kortbeek (Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, the Netherlands) is thanked for the primary molecular diagnosis of ML and Leishmania species determination in the first biopsy specimen.

Publisher Copyright:
© 2021 The Authors

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Painful and swollen tongue, mucosal leishmaniasis due to Leishmania infantumFinal published version, 625 KBLicence: CC BY-NC-ND

Cite this

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title = "Painful and swollen tongue: mucosal leishmaniasis due to Leishmania infantum",

abstract = "Background:: Leishmaniasis is a parasitic disease caused by different Leishmania species. L. infantum is found in the Mediterranean area. It usually causes visceral or cutaneous leishmaniasis, but rarely mucosal leishmaniasis (ML). Methods:: A 62-year-old man with metastatic non-small-cell lung carcinoma visited the outpatient clinic because of a painful and swollen tongue. Initially, oral candidiasis was suspected and patient was unsuccessfully treated accordingly. Subsequently, a biopsy from the tongue was taken. Results:: Histology of the tongue biopsy showed an inflammation with histiocytes and Leishmania amastigotes. Molecular analysis determined these parasites as L. donovani complex. Based on the patient's travel history, ML caused by L. infantum was diagnosed. Conclusion:: ML is an unusual presentation of L. infantum. ML is not only caused by Leishmania species endemic in Latin America, but also should be considered in the differential diagnosis for European patients. A biopsy of the affected location is needed to confirm the diagnosis.",

author = "Chong, \{Ga Lai M.\} and Ong, \{David SY\} and \{de Mendon{\c c}a Melo\}, Mariana and \{van Hellemond\}, \{Jaap J.\}",

note = "Funding Information: We would like to thank Suzanna Broerse (Franciscus Gasthuis \& Vlietland, Rotterdam, the Netherlands) for supplying specific clinical information and Klaas Hoogduin (Franciscus Gasthuis \& Vlietland, Rotterdam, the Netherlands) for analysing and describing the histologic specimen. Titia Kortbeek (Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, the Netherlands) is thanked for the primary molecular diagnosis of ML and Leishmania species determination in the first biopsy specimen. Publisher Copyright: {\textcopyright} 2021 The Authors",

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doi = "10.1016/j.ijid.2021.09.071",

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AU - Chong, Ga Lai M.

AU - Ong, David SY

AU - de Mendonça Melo, Mariana

AU - van Hellemond, Jaap J.

N1 - Funding Information: We would like to thank Suzanna Broerse (Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands) for supplying specific clinical information and Klaas Hoogduin (Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands) for analysing and describing the histologic specimen. Titia Kortbeek (Laboratory for Infectious Diseases, National Institute for Public Health and the Environment, Bilthoven, the Netherlands) is thanked for the primary molecular diagnosis of ML and Leishmania species determination in the first biopsy specimen. Publisher Copyright: © 2021 The Authors

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Background:: Leishmaniasis is a parasitic disease caused by different Leishmania species. L. infantum is found in the Mediterranean area. It usually causes visceral or cutaneous leishmaniasis, but rarely mucosal leishmaniasis (ML). Methods:: A 62-year-old man with metastatic non-small-cell lung carcinoma visited the outpatient clinic because of a painful and swollen tongue. Initially, oral candidiasis was suspected and patient was unsuccessfully treated accordingly. Subsequently, a biopsy from the tongue was taken. Results:: Histology of the tongue biopsy showed an inflammation with histiocytes and Leishmania amastigotes. Molecular analysis determined these parasites as L. donovani complex. Based on the patient's travel history, ML caused by L. infantum was diagnosed. Conclusion:: ML is an unusual presentation of L. infantum. ML is not only caused by Leishmania species endemic in Latin America, but also should be considered in the differential diagnosis for European patients. A biopsy of the affected location is needed to confirm the diagnosis.

AB - Background:: Leishmaniasis is a parasitic disease caused by different Leishmania species. L. infantum is found in the Mediterranean area. It usually causes visceral or cutaneous leishmaniasis, but rarely mucosal leishmaniasis (ML). Methods:: A 62-year-old man with metastatic non-small-cell lung carcinoma visited the outpatient clinic because of a painful and swollen tongue. Initially, oral candidiasis was suspected and patient was unsuccessfully treated accordingly. Subsequently, a biopsy from the tongue was taken. Results:: Histology of the tongue biopsy showed an inflammation with histiocytes and Leishmania amastigotes. Molecular analysis determined these parasites as L. donovani complex. Based on the patient's travel history, ML caused by L. infantum was diagnosed. Conclusion:: ML is an unusual presentation of L. infantum. ML is not only caused by Leishmania species endemic in Latin America, but also should be considered in the differential diagnosis for European patients. A biopsy of the affected location is needed to confirm the diagnosis.

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SN - 1201-9712

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JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Painful and swollen tongue: mucosal leishmaniasis due to Leishmania infantum

Abstract

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