Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naive ferrets

B Baras, Leon Waal, Koert Stittelaar, V Jacob, S Giannini, Edwin Veldhuis Kroeze, Judith van den Brand, Geert Amerongen, JH Simon, E Hanon, SP Mossman, Ab Osterhaus

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In the context of an A/H1N1 influenza pandemic situation, this study demonstrates that heterologous vaccination with an AS03-adjuvanted 2008/2009 seasonal trivalent and pandemic H5N1 monovalent split vaccine conferred partial protection in influenza-naive ferrets after challenge with the influenza pandemic H1N1 A/The Netherlands/602/09 virus. Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naive ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets. (C) 2011 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)2120-2126
Number of pages7
Issue number11
Publication statusPublished - 2011

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