Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart; G. J. de Vos; G. J. te Meerman; A. G. Uitterlinden; J. Vijg

doi:10.1038/365469a0

Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart^*
, G. J. de Vos
, G. J. te Meerman
, A. G. Uitterlinden
, J. Vijg

^*Corresponding author for this work

INGENY B.V.
Medscand Ingeny

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

Original language	English
Pages (from-to)	469-471
Number of pages	3
Journal	Nature
Volume	365
Issue number	6445
DOIs	https://doi.org/10.1038/365469a0
Publication status	Published - 30 Sept 1993
Externally published	Yes

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title = "Parallel genome analysis by two-dimensional DNA typing.",

abstract = "By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.",

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AU - Mullaart, E.

AU - de Vos, G. J.

AU - te Meerman, G. J.

AU - Uitterlinden, A. G.

AU - Vijg, J.

PY - 1993/9/30

Y1 - 1993/9/30

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AB - By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

UR - https://www.scopus.com/pages/publications/0027926585

U2 - 10.1038/365469a0

DO - 10.1038/365469a0

M3 - Article

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SN - 0028-0836

VL - 365

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JO - Nature

JF - Nature

IS - 6445

ER -

Parallel genome analysis by two-dimensional DNA typing.

Abstract

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