Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

VJ (Vincent) Munster; E (Emmie) de Wit; Judith van den Brand; Sander Herfst; Eefje Schrauwen; Theo Bestebroer; David van de Vijver; Charles Boucher; Marion Koopmans; Guus Rimmelzwaan; Thijs Kuiken; Ab Osterhaus; Ron Fouchier

doi:10.1126/science.1177127

Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

VJ (Vincent) Munster, E (Emmie) de Wit, Judith van den Brand, Sander Herfst, Eefje Schrauwen, Theo Bestebroer, David van de Vijver, Charles Boucher, Marion Koopmans, Guus Rimmelzwaan, Thijs Kuiken, Ab Osterhaus, Ron Fouchier

Virology

Research output: Contribution to journal › Article › Academic › peer-review

531 Citations (Scopus)

Abstract

The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

Original language	Undefined/Unknown
Pages (from-to)	481-483
Number of pages	3
Journal	Science
Volume	325
Issue number	5939
DOIs	https://doi.org/10.1126/science.1177127
Publication status	Published - 2009

Research programs

EMC MM-04-27-01

Access to Document

10.1126/science.1177127

http://hdl.handle.net/1765/25229

Cite this

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title = "Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets",

abstract = "The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.",

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T1 - Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

AU - Munster, VJ (Vincent)

AU - de Wit, E (Emmie)

AU - van den Brand, Judith

AU - Herfst, Sander

AU - Schrauwen, Eefje

AU - Bestebroer, Theo

AU - van de Vijver, David

AU - Boucher, Charles

AU - Koopmans, Marion

AU - Rimmelzwaan, Guus

AU - Kuiken, Thijs

AU - Osterhaus, Ab

AU - Fouchier, Ron

PY - 2009

Y1 - 2009

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AB - The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

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