Pathogenicity of highly pathogenic avian influenza virus in mammals

E (Emmie) de Wit; Y Kawaoka; MD de Jong; Ron Fouchier

doi:10.1016/j.vaccine.2008.07.072

Pathogenicity of highly pathogenic avian influenza virus in mammals

E (Emmie) de Wit, Y Kawaoka, MD de Jong, Ron Fouchier

Virology

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity. (c) 2008 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	D54-D58
Journal	Vaccine
Volume	26
DOIs	https://doi.org/10.1016/j.vaccine.2008.07.072
Publication status	Published - 2008

Research programs

EMC MM-04-27-01

Access to Document

10.1016/j.vaccine.2008.07.072

http://hdl.handle.net/1765/29459

Cite this

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title = "Pathogenicity of highly pathogenic avian influenza virus in mammals",

abstract = "In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity. (c) 2008 Elsevier Ltd. All rights reserved.",

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AU - Kawaoka, Y

AU - de Jong, MD

AU - Fouchier, Ron

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AB - In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity. (c) 2008 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.vaccine.2008.07.072

M3 - Article

C2 - 19230161

SN - 0264-410X

VL - 26

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