Pathological Q Waves in Myocardial Infarction in Patients Treated by Primary PCI

R Delewi, G IJff, TP van de Hoef, Alexander Hirsch, LF Robbers, R Nijveldt, AM van der Laan, PA van der Vleuten, C Lucas, J Tijssen, AC van Rossum, Felix Zijlstra, JJ Piek

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OBJECTIVES In the present study, we investigated the association of pathological Q waves with infarct size. Furthermore, we investigated whether Q-wave regression was associated with improvement of left ventricular ejection fraction (LVEF), infarct size, and left ventricular dimensions in ST-segment elevation myocardial infarction (STEMI) patients with early Q-wave formation compared with patients without or persistent pathological Q waves. BACKGROUND The criteria for pathological Q waves after acute myocardial infarction (MI) have changed over the years. Also, there are limited data regarding correlation of Q-wave regression and preservation of LVEF in patients with an initial Q-wave MI. METHODS Standard 12-lead electrocardiograms (ECGs) were recorded in 184 STEMI patients treated with primary percutaneous coronary intervention (PCI). ECGs were recorded before and following PCI, as well as at 1, 4, 12, and 24 months of follow-up. An ECG was scored as Q-wave MI when it showed Q waves in 2 or more contiguous leads according to the 4 readily available clinical definitions used over the years: "classic" criteria, Thrombolysis In Myocardial Infarction criteria, and 2000 and 2007 cons RESULTS The classic ECG criteria showed strongest correlation with infarct size as measured by CMR. The incidence of Q-wave MI according to the classic criteria was 23% 1 h after PCI. At 24 months of follow-up, 40% of patients with initial Q-wave MI displayed Q-wave regression. Patients with a Q-wave MI had larger infarct size and lower LVEF on baseline CMR (24 +/- 10% LV mass and 37 +/- 8%, respectively) compared with patients with non-Q-wave MI (17 +/- 9% LV mass, p < 0.01, and 45 +/- 8%, p < CONCLUSIONS Association of Q waves with infarct size is strongest when using the classic Q-wave criteria. Q-wave regression is associated with the largest improvement of LVEF as assessed with CMR. (J Am Coll Cardiol Img 2013; 6: 324-31) (C) 2013 by the American College of Cardiology Foundation
Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalJACC-cardiovascular imaging
Issue number3
Publication statusPublished - 2013


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