Pathophysiology of peri-articular bone changes in osteoarthritis

HH Weinans, Michiel Siebelt, Rintje Agricola, Sander Botter, Tom Piscaer, Jan Waarsing

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Osteoarthritis (OA) is a disease that involves the entire joint, but its pathophysiology is not well described. Alterations in peri-articular bone are an integral part of the OA disease process and different aspects of bone changes have been described in different patient (sub)groups and animal models. In this review we will discuss the osteoarthritis pathophysiology from the perspective of periarticular bone changes, which can be considered at three hierarchical levels: the bone (or joint) shape, the subchondral bone architecture and its cellular and molecular phenotype. In this review we try to provide an overview of the current knowledge of peri-articular bone changes in OA and what it could possibly imply for the initiation of OA and its progression. This article is part of a Special Issue entitled "Osteoarthritis". (C) 2012 Elsevier Inc. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)190-196
Number of pages7
Issue number2
Publication statusPublished - 2012

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  • EMC MM-01-51-01

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