PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

AF Schmidt; DI Swerdlow; MV Holmes; RS Patel; Z Fairhurst-Hunter; DM Lyall; FP Hartwig; BL Horta; E Hypponen; C Power; M Moldovan; E van Iperen; GK Hovingh; I Demuth; K Norman; E Steinhagen-Thiessen; J Demuth; L Bertram; T Liu; S Coassin; J Willeit; S Kiechl; K Willeit; D Mason; J Wright; R Morris; G Wanamethee; P Whincup; Y Ben-Shlomo; S McLachlan; JF Price; M Kivimaki; C Welch; A Sanchez-Galvez; P Marques-Vidal; A Nicolaides; AG Panayiotou; NC Onland-Moret; YT van der Schouw; G Matullo; G Fiorito; S Guarrera; C Sacerdote; NJ Wareham; C Langenberg; R Scott; JA Luan; M Bobak; SA Malyutina; A Pajak; R Kubinova; A Tamosiunas; H Pikhart; LLN Husemoen; N Grarup; O Pedersen; T Hansen; A Linneberg; KS Simonsen; J Cooper; SE Humphries; M Brilliant; T Kitchner; H Hakonarson; DS Carrell; CA McCarty; HL Kirchner; EB Larson; DR Crosslin; M de Andrade; DM Roden; JC Denny; C Carty; S Hancock; J Attia; E Holliday; MO Donnell; S Yusuf; M Chong; G Pare; P van der Harst; MA Said; RN Eppinga; N Verweij; H Snieder; T Christen; DO Mook-Kanamori; S Gustafsson; L Lind; E Ingelsson; Raha Pazoki; OH Franco Duran; Bert Hofman; André Uitterlinden; Abbas Dehghan; A Teumer; S Baumeister; M Dorr; MM Lerch; U Volker; H Volzke; J Ward; JP Pell; Derek Smith; T Meade; AH Zee; EV Baranova; R Young; I Ford; A (Archie) Campbell; S Padmanabhan; ML Bots; DE Grobbee; P Froguel; D Thuillier; B Balkau; A Bonnefond; B Cariou; M Smart; Y Bao; M Kumari; A Mahajan; PM Ridker; DI Chasman; AP Reiner; LA Lange; MD Ritchie; FW Asselbergs; JP Casas; BJ Keating; D Preiss; AD Hingorani; N Sattar

doi:10.1016/s2213-8587(16)30396-5

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

AF Schmidt
, DI Swerdlow
, MV Holmes
, RS Patel
, Z Fairhurst-Hunter
, DM Lyall
, FP Hartwig
, BL Horta
, E Hypponen
, C Power
, M Moldovan
, E van Iperen
, GK Hovingh
, I Demuth
, K Norman
, E Steinhagen-Thiessen
, J Demuth
, L Bertram
, T Liu
, S Coassin

J Willeit, S Kiechl, K Willeit, D Mason, J Wright, R Morris, G Wanamethee, P Whincup, Y Ben-Shlomo, S McLachlan, JF Price, M Kivimaki, C Welch, A Sanchez-Galvez, P Marques-Vidal, A Nicolaides, AG Panayiotou, NC Onland-Moret, YT van der Schouw, G Matullo, G Fiorito, S Guarrera, C Sacerdote, NJ Wareham, C Langenberg, R Scott, JA Luan, M Bobak, SA Malyutina, A Pajak, R Kubinova, A Tamosiunas, H Pikhart, LLN Husemoen, N Grarup, O Pedersen, T Hansen, A Linneberg, KS Simonsen, J Cooper, SE Humphries, M Brilliant, T Kitchner, H Hakonarson, DS Carrell, CA McCarty, HL Kirchner, EB Larson, DR Crosslin, M de Andrade, DM Roden, JC Denny, C Carty, S Hancock, J Attia, E Holliday, MO Donnell, S Yusuf, M Chong, G Pare, P van der Harst, MA Said, RN Eppinga, N Verweij, H Snieder, T Christen, DO Mook-Kanamori, S Gustafsson, L Lind, E Ingelsson, Raha Pazoki, OH Franco Duran, Bert Hofman, André Uitterlinden, Abbas Dehghan, A Teumer, S Baumeister, M Dorr, MM Lerch, U Volker, H Volzke, J Ward, JP Pell, Derek Smith, T Meade, AH Zee, EV Baranova, R Young, I Ford, A (Archie) Campbell, S Padmanabhan, ML Bots, DE Grobbee, P Froguel, D Thuillier, B Balkau, A Bonnefond, B Cariou, M Smart, Y Bao, M Kumari, A Mahajan, PM Ridker, DI Chasman, AP Reiner, LA Lange, MD Ritchie, FW Asselbergs, JP Casas, BJ Keating, D Preiss, AD Hingorani, N Sattar

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Research output: Contribution to journal › Article › Academic › peer-review

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19 Downloads (Pure)

Original language	Undefined/Unknown
Pages (from-to)	97-105
Number of pages	9
Journal	The Lancet Diabetes & Endocrinology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/s2213-8587(16)30396-5
Publication status	Published - 2017

Research programs

EMC OR-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s2213-8587(16)30396-5

REPUB_95234_OA.pdfFinal published version, 595 KB

http://hdl.handle.net/1765/95234

Cite this

Schmidt, AF., Swerdlow, DI., Holmes, MV., Patel, RS., Fairhurst-Hunter, Z., Lyall, DM., Hartwig, FP., Horta, BL., Hypponen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, GK., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., ... Sattar, N. (2017). PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet Diabetes & Endocrinology, 5(2), 97-105. https://doi.org/10.1016/s2213-8587(16)30396-5

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title = "PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study",

author = "AF Schmidt and DI Swerdlow and MV Holmes and RS Patel and Z Fairhurst-Hunter and DM Lyall and FP Hartwig and BL Horta and E Hypponen and C Power and M Moldovan and \{van Iperen\}, E and GK Hovingh and I Demuth and K Norman and E Steinhagen-Thiessen and J Demuth and L Bertram and T Liu and S Coassin and J Willeit and S Kiechl and K Willeit and D Mason and J Wright and R Morris and G Wanamethee and P Whincup and Y Ben-Shlomo and S McLachlan and JF Price and M Kivimaki and C Welch and A Sanchez-Galvez and P Marques-Vidal and A Nicolaides and AG Panayiotou and NC Onland-Moret and \{van der Schouw\}, YT and G Matullo and G Fiorito and S Guarrera and C Sacerdote and NJ Wareham and C Langenberg and R Scott and JA Luan and M Bobak and SA Malyutina and A Pajak and R Kubinova and A Tamosiunas and H Pikhart and LLN Husemoen and N Grarup and O Pedersen and T Hansen and A Linneberg and KS Simonsen and J Cooper and SE Humphries and M Brilliant and T Kitchner and H Hakonarson and DS Carrell and CA McCarty and HL Kirchner and EB Larson and DR Crosslin and \{de Andrade\}, M and DM Roden and JC Denny and C Carty and S Hancock and J Attia and E Holliday and MO Donnell and S Yusuf and M Chong and G Pare and \{van der Harst\}, P and MA Said and RN Eppinga and N Verweij and H Snieder and T Christen and DO Mook-Kanamori and S Gustafsson and L Lind and E Ingelsson and Raha Pazoki and \{Franco Duran\}, OH and Bert Hofman and Andr{\'e} Uitterlinden and Abbas Dehghan and A Teumer and S Baumeister and M Dorr and MM Lerch and U Volker and H Volzke and J Ward and JP Pell and Derek Smith and T Meade and AH Zee and EV Baranova and R Young and I Ford and Campbell, \{A (Archie)\} and S Padmanabhan and ML Bots and DE Grobbee and P Froguel and D Thuillier and B Balkau and A Bonnefond and B Cariou and M Smart and Y Bao and M Kumari and A Mahajan and PM Ridker and DI Chasman and AP Reiner and LA Lange and MD Ritchie and FW Asselbergs and JP Casas and BJ Keating and D Preiss and AD Hingorani and N Sattar",

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doi = "10.1016/s2213-8587(16)30396-5",

language = "Undefined/Unknown",

volume = "5",

pages = "97--105",

journal = "The Lancet Diabetes \& Endocrinology",

issn = "2213-8587",

publisher = "Firenze University Press",

number = "2",

}

Schmidt, AF, Swerdlow, DI, Holmes, MV, Patel, RS, Fairhurst-Hunter, Z, Lyall, DM, Hartwig, FP, Horta, BL, Hypponen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, GK, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, JF, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, AG, Onland-Moret, NC, van der Schouw, YT, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, NJ, Langenberg, C, Scott, R, Luan, JA, Bobak, M, Malyutina, SA, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, LLN, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, KS, Cooper, J, Humphries, SE, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, DS, McCarty, CA, Kirchner, HL, Larson, EB, Crosslin, DR, de Andrade, M, Roden, DM, Denny, JC, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, MO, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, MA, Eppinga, RN, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, DO, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco Duran, OH, Hofman, B, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dorr, M, Lerch, MM, Volker, U, Volzke, H, Ward, J, Pell, JP, Smith, D, Meade, T, Zee, AH, Baranova, EV, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, ML, Grobbee, DE, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, PM, Chasman, DI, Reiner, AP, Lange, LA, Ritchie, MD, Asselbergs, FW, Casas, JP, Keating, BJ, Preiss, D, Hingorani, AD & Sattar, N 2017, 'PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study', The Lancet Diabetes & Endocrinology, vol. 5, no. 2, pp. 97-105. https://doi.org/10.1016/s2213-8587(16)30396-5

TY - JOUR

T1 - PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

AU - Schmidt, AF

AU - Swerdlow, DI

AU - Holmes, MV

AU - Patel, RS

AU - Fairhurst-Hunter, Z

AU - Lyall, DM

AU - Hartwig, FP

AU - Horta, BL

AU - Hypponen, E

AU - Power, C

AU - Moldovan, M

AU - van Iperen, E

AU - Hovingh, GK

AU - Demuth, I

AU - Norman, K

AU - Steinhagen-Thiessen, E

AU - Demuth, J

AU - Bertram, L

AU - Liu, T

AU - Coassin, S

AU - Willeit, J

AU - Kiechl, S

AU - Willeit, K

AU - Mason, D

AU - Wright, J

AU - Morris, R

AU - Wanamethee, G

AU - Whincup, P

AU - Ben-Shlomo, Y

AU - McLachlan, S

AU - Price, JF

AU - Kivimaki, M

AU - Welch, C

AU - Sanchez-Galvez, A

AU - Marques-Vidal, P

AU - Nicolaides, A

AU - Panayiotou, AG

AU - Onland-Moret, NC

AU - van der Schouw, YT

AU - Matullo, G

AU - Fiorito, G

AU - Guarrera, S

AU - Sacerdote, C

AU - Wareham, NJ

AU - Langenberg, C

AU - Scott, R

AU - Luan, JA

AU - Bobak, M

AU - Malyutina, SA

AU - Pajak, A

AU - Kubinova, R

AU - Tamosiunas, A

AU - Pikhart, H

AU - Husemoen, LLN

AU - Grarup, N

AU - Pedersen, O

AU - Hansen, T

AU - Linneberg, A

AU - Simonsen, KS

AU - Cooper, J

AU - Humphries, SE

AU - Brilliant, M

AU - Kitchner, T

AU - Hakonarson, H

AU - Carrell, DS

AU - McCarty, CA

AU - Kirchner, HL

AU - Larson, EB

AU - Crosslin, DR

AU - de Andrade, M

AU - Roden, DM

AU - Denny, JC

AU - Carty, C

AU - Hancock, S

AU - Attia, J

AU - Holliday, E

AU - Donnell, MO

AU - Yusuf, S

AU - Chong, M

AU - Pare, G

AU - van der Harst, P

AU - Said, MA

AU - Eppinga, RN

AU - Verweij, N

AU - Snieder, H

AU - Christen, T

AU - Mook-Kanamori, DO

AU - Gustafsson, S

AU - Lind, L

AU - Ingelsson, E

AU - Pazoki, Raha

AU - Franco Duran, OH

AU - Hofman, Bert

AU - Uitterlinden, André

AU - Dehghan, Abbas

AU - Teumer, A

AU - Baumeister, S

AU - Dorr, M

AU - Lerch, MM

AU - Volker, U

AU - Volzke, H

AU - Ward, J

AU - Pell, JP

AU - Smith, Derek

AU - Meade, T

AU - Zee, AH

AU - Baranova, EV

AU - Young, R

AU - Ford, I

AU - Campbell, A (Archie)

AU - Padmanabhan, S

AU - Bots, ML

AU - Grobbee, DE

AU - Froguel, P

AU - Thuillier, D

AU - Balkau, B

AU - Bonnefond, A

AU - Cariou, B

AU - Smart, M

AU - Bao, Y

AU - Kumari, M

AU - Mahajan, A

AU - Ridker, PM

AU - Chasman, DI

AU - Reiner, AP

AU - Lange, LA

AU - Ritchie, MD

AU - Asselbergs, FW

AU - Casas, JP

AU - Keating, BJ

AU - Preiss, D

AU - Hingorani, AD

AU - Sattar, N

PY - 2017

Y1 - 2017

U2 - 10.1016/s2213-8587(16)30396-5

DO - 10.1016/s2213-8587(16)30396-5

M3 - Article

SN - 2213-8587

VL - 5

SP - 97

EP - 105

JO - The Lancet Diabetes & Endocrinology

JF - The Lancet Diabetes & Endocrinology

IS - 2

ER -