Pediatric Microdose and Microtracer Studies Using C-14 in Europe

MA Turner, Miriam Mooij, WHJ Vaes, AD Windhorst, NH Hendrikse, CAJ Knibbe, LT Korgvee, W Maruszak, G Grynkiewicz, RC Garner, Dick Tibboel, BK Park, Saskia de Wildt

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)


Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientific challenges. One barrier to the evaluation of medicines for children is a lack of innovative methodologies that have been adapted to the needs of children. This article presents our successful experience of pediatric microdose and microtracer studies using C-14-labeled probes in Europe to illustrate the strengths and limitations of these approaches.
Original languageUndefined/Unknown
Pages (from-to)234-237
Number of pages4
JournalClinical Pharmacology & Therapeutics
Issue number3
Publication statusPublished - 2015

Cite this