Performance improvements of stool-based screening tests

Leonie Dam; Ernst Kuipers; M Leerdam

doi:10.1016/j.bpg.2010.03.009

Performance improvements of stool-based screening tests

Leonie Dam, Ernst Kuipers, M Leerdam

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

40 Citations (Scopus)

Abstract

Stool testing is a widely accepted, non-invasive, technique for colorectal cancer (CRC) screening. Guaiac-based faecal occult blood test (gFOBT) screening has been proven to decrease CRC-related mortality; however gFOBT is hampered by a low sensitivity. Faecal immunochemical tests (FITS) have several advantages over gFOBT. First of all, FIT has a better sensitivity and higher uptake. Furthermore, the quantitative variant of the FIT allows choices on cut-off level for test-positivity according to colonoscopy resources available, personal risk profile, and/or intended detection rate in the screened population. Stool-based DNA (sDNA) tests aiming at the detection of specific DNA alterations may improve detection of CRC and adenomas compared to gFOBT screening, but large-scale population based studies are lacking. This review focuses on factors influencing test performance of those three stool based screening tests. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	479-492
Number of pages	14
Journal	Best Practice & Research in Clinical Gastroenterology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.bpg.2010.03.009
Publication status	Published - 2010

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bpg.2010.03.009

http://hdl.handle.net/1765/26039

Cite this

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abstract = "Stool testing is a widely accepted, non-invasive, technique for colorectal cancer (CRC) screening. Guaiac-based faecal occult blood test (gFOBT) screening has been proven to decrease CRC-related mortality; however gFOBT is hampered by a low sensitivity. Faecal immunochemical tests (FITS) have several advantages over gFOBT. First of all, FIT has a better sensitivity and higher uptake. Furthermore, the quantitative variant of the FIT allows choices on cut-off level for test-positivity according to colonoscopy resources available, personal risk profile, and/or intended detection rate in the screened population. Stool-based DNA (sDNA) tests aiming at the detection of specific DNA alterations may improve detection of CRC and adenomas compared to gFOBT screening, but large-scale population based studies are lacking. This review focuses on factors influencing test performance of those three stool based screening tests. (C) 2010 Elsevier Ltd. All rights reserved.",

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AU - Kuipers, Ernst

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AB - Stool testing is a widely accepted, non-invasive, technique for colorectal cancer (CRC) screening. Guaiac-based faecal occult blood test (gFOBT) screening has been proven to decrease CRC-related mortality; however gFOBT is hampered by a low sensitivity. Faecal immunochemical tests (FITS) have several advantages over gFOBT. First of all, FIT has a better sensitivity and higher uptake. Furthermore, the quantitative variant of the FIT allows choices on cut-off level for test-positivity according to colonoscopy resources available, personal risk profile, and/or intended detection rate in the screened population. Stool-based DNA (sDNA) tests aiming at the detection of specific DNA alterations may improve detection of CRC and adenomas compared to gFOBT screening, but large-scale population based studies are lacking. This review focuses on factors influencing test performance of those three stool based screening tests. (C) 2010 Elsevier Ltd. All rights reserved.

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